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Dual-Echo Arterial Spin Labeling for Brain Perfusion Quantification and Functional Analysis
Joint Authors
Paschoal, André Monteiro
Paiva, Fernando Fernandes
Leoni, Renata Ferranti
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-08-01
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Arterial Spin Labeling (ASL) is a noninvasive MRI-based method to measure cerebral blood flow (CBF).
Recently, the study of ASL as a functional tool has emerged once CBF fluctuation comes from capillaries in brain tissue, giving a more spatially specific response when compared to the standard functional MRI method, based on the blood oxygenation level-dependent (BOLD) contrast.
Although the BOLD effect could be desirable to study brain function, if one aims to quantify CBF, such effect is considered contamination that can be more attenuated if short TE value is used in the image acquisition.
An approach that provides both CBF and function information in a simultaneous acquisition is the use of a dual-echo ASL (DE-ASL) readout.
Our purpose was to evaluate the information provided by DE-ASL regarding CBF quantification and functional connectivity with a motor task.
Pseudocontinuous ASL of twenty healthy subjects (age: 32.4 ± 10.2 years, 13 male) was acquired at a 3T scanner.
We analyzed the influence of TE on CBF values and brain connectivity provided by CBF and concurrent BOLD (cc-BOLD) time series.
Brain networks were obtained by the general linear model and independent component analysis.
Connectivity matrices were generated using a bivariate correlation (Fisher Z values).
No effect of the sequence readout, but significant effect of the TE value, was observed on gray matter CBF values.
Motor networks with reduced extension and more connections with important regions for brain integration were observed for CBF data acquired with short TE, proving its higher spatial specificity.
Therefore, it was possible to use a dual-echo readout provided by a standard commercial ASL pulse sequence to obtain reliable quantitative CBF values and functional information simultaneously.
American Psychological Association (APA)
Paschoal, André Monteiro& Paiva, Fernando Fernandes& Leoni, Renata Ferranti. 2019. Dual-Echo Arterial Spin Labeling for Brain Perfusion Quantification and Functional Analysis. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1130804
Modern Language Association (MLA)
Paschoal, André Monteiro…[et al.]. Dual-Echo Arterial Spin Labeling for Brain Perfusion Quantification and Functional Analysis. No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1130804
American Medical Association (AMA)
Paschoal, André Monteiro& Paiva, Fernando Fernandes& Leoni, Renata Ferranti. Dual-Echo Arterial Spin Labeling for Brain Perfusion Quantification and Functional Analysis. . 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1130804
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130804