Alpha-Fetoprotein as a Predictive Marker for Patients with Hepatitis B-Related Acute-on-Chronic Liver Failure
Joint Authors
Wang, Xiaoping
Shen, Caifei
Yang, Jianjiang
Yang, Xianjun
Qin, Sen
Zeng, Haijun
Wu, Xiaoling
Tang, Shanhong
Zeng, Weizheng
Source
Canadian Journal of Gastroenterology and Hepatology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-09
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background and Aims.
The value of alpha-fetoprotein (AFP) in hepatitis B-related acute-on-chronic liver failure (HBACLF) is not fully understood.
The present study aimed to evaluate the prognostic effect of AFP on the prediction of HBACLF outcomes.
Methods.
We investigated a cohort of patients with HBACLF admitted from January 2013 to May 2017.
The endpoint of followup was 180 days, death, or liver transplantation.
AFP concentrations were estimated on admission.
To make statistical comparisons, we used chi-squared test, receiver operating characteristic (ROC) curve analysis, survivorship curve analysis, and Cox proportional-hazards model.
Results.
A total of 92 patients (81.5% male, median age of 46 years) were included.
Overall survival rate within 180 days was 43.48%, and the value of log10AFP ≥ 2.04 indicated a better prognosis with 76.9% specificity and 62.5% sensitivity for patients with HBACLF.
Age (HR 1.041), total bilirubin (HR 1.004), log10AFP (HR 2.155), and INR (HR 1.446) were found to be risk factors of survival.
Conclusion.
AFP could be a useful marker to predict outcomes of acute-on-chronic liver failure.
American Psychological Association (APA)
Wang, Xiaoping& Shen, Caifei& Yang, Jianjiang& Yang, Xianjun& Qin, Sen& Zeng, Haijun…[et al.]. 2018. Alpha-Fetoprotein as a Predictive Marker for Patients with Hepatitis B-Related Acute-on-Chronic Liver Failure. Canadian Journal of Gastroenterology and Hepatology،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1130869
Modern Language Association (MLA)
Wang, Xiaoping…[et al.]. Alpha-Fetoprotein as a Predictive Marker for Patients with Hepatitis B-Related Acute-on-Chronic Liver Failure. Canadian Journal of Gastroenterology and Hepatology No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1130869
American Medical Association (AMA)
Wang, Xiaoping& Shen, Caifei& Yang, Jianjiang& Yang, Xianjun& Qin, Sen& Zeng, Haijun…[et al.]. Alpha-Fetoprotein as a Predictive Marker for Patients with Hepatitis B-Related Acute-on-Chronic Liver Failure. Canadian Journal of Gastroenterology and Hepatology. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1130869
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130869