Preoperative Thrombocytopenia May Predict Poor Surgical Outcome after Extended Hepatectomy
Joint Authors
Mieth, Markus
Hackert, Thilo
Golriz, Mohammad
Ghamarnejad, Omid
Khajeh, Elias
Sabagh, Mohammadsadegh
Hoffmann, Katrin
Ulrich, Alexis
Weiss, Karl Heinz
Mehrabi, Arianeb
Büchler, Markus W.
Schirmacher, Peter
Source
Canadian Journal of Gastroenterology and Hepatology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-01
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
It is a novel idea that platelet counts may be associated with postoperative outcome following liver surgery.
This may help in planning an extended hepatectomy (EH), which is a surgical procedure with high morbidity and mortality.
Aim.
The aim of this study was to evaluate the predictive potential of platelet counts on the outcome of EH in patients without portal hypertension, splenomegaly, or cirrhosis.
Methods.
A series of 213 consecutive patients underwent EH (resection of ≥ five liver segments) between 2001 and 2016.
The association of preoperative platelet counts with posthepatectomy liver failure (PHLF), morbidity (based on Clavien-Dindo classification), and 30-day mortality was evaluated using multivariate analysis.
Results.
PHLF was detected in 26.3% of patients, major complications in 26.8%, and 30-day mortality in 11.3% of patients.
Multivariate analysis revealed that the preoperative platelet count is an independent predictor of PHLF (odds ratio [OR] 4.4, 95% confidence interval [CI] 1.3–15.0, p=0.020) and 30-day mortality (OR 4.4, 95% CI 1.1–18.8, p=0.043).
Conclusions.
Preoperative platelet count is associated with PHLF and mortality following extended liver resection.
This association was independent of other related parameters.
Prospective studies are needed to evaluate the predictive role and to determine the impact of preoperative correction of platelet count on postoperative outcomes after EH.
American Psychological Association (APA)
Golriz, Mohammad& Ghamarnejad, Omid& Khajeh, Elias& Sabagh, Mohammadsadegh& Mieth, Markus& Hoffmann, Katrin…[et al.]. 2018. Preoperative Thrombocytopenia May Predict Poor Surgical Outcome after Extended Hepatectomy. Canadian Journal of Gastroenterology and Hepatology،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1130871
Modern Language Association (MLA)
Golriz, Mohammad…[et al.]. Preoperative Thrombocytopenia May Predict Poor Surgical Outcome after Extended Hepatectomy. Canadian Journal of Gastroenterology and Hepatology No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1130871
American Medical Association (AMA)
Golriz, Mohammad& Ghamarnejad, Omid& Khajeh, Elias& Sabagh, Mohammadsadegh& Mieth, Markus& Hoffmann, Katrin…[et al.]. Preoperative Thrombocytopenia May Predict Poor Surgical Outcome after Extended Hepatectomy. Canadian Journal of Gastroenterology and Hepatology. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1130871
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130871