48-Week Outcome after Cessation of Nucleos(t)ide Analogue Treatment in Chronic Hepatitis B Patient and the Associated Factors with Relapse
Joint Authors
Xiang, Zhu
Peng, Liang
Xie, Dongying
Xie, Chan
Zhao, Zhixin
Lin, Chao-shuang
Xu, Wen-xiong
Gao, Zhi L.
Deng, Hong
Zhang, Qian
Chen, You-ming
Mei, Yong-yu
Source
Canadian Journal of Gastroenterology and Hepatology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-10
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background and Aims.
We aimed to ascertain the feasibility and safety of NA cessation, the status of patients after cessation, and the predictive factors for relapse and subsequent retreatment.
Methods.
A total of 92 patients were enrolled in this prospective study.
Patients were monitored every month for the first 3 months after cessation and every 3 months thereafter.
Results.
Sixty-two patients finished 48 weeks of follow-up.
None died or developed liver failure, cirrhosis, or HCC.
The 62 patients could be divided into 4 categories according to the 48-week clinical development of relapse.
Virologic relapses occurred in 39 (62.9%) patients, with 72.7% occurring in the first 24 weeks in origin HBeAg positive patients and 82.4% in the first 12 weeks in origin HBeAg negative patients.
Age (OR = 1.06, 95% CI = 1.02–1.10; p=0.003), the HBsAg level (OR = 2.21, 95% CI = 1.47–3.32; p<0.001), and positive origin HBeAg status (OR = 0.32, 95% CI = 0.14–0.74; p=0.008) were predictive factors to virologic relapse.
HBV DNA level (OR = 1.34, 95% CI = 1.13–1.58; p<0.001) was predictive factor to retreatment.
Conclusions.
NA cessation is safe under supervision.
Age, HBsAg level, and origin HBeAg status can be predictive factors for virologic relapse.
The study was submitted to ClinicalTrials.gov Protocol Registration and Results System with the assigned NCT ID NCT02883647.
American Psychological Association (APA)
Xu, Wen-xiong& Zhang, Qian& Xiang, Zhu& Lin, Chao-shuang& Chen, You-ming& Deng, Hong…[et al.]. 2018. 48-Week Outcome after Cessation of Nucleos(t)ide Analogue Treatment in Chronic Hepatitis B Patient and the Associated Factors with Relapse. Canadian Journal of Gastroenterology and Hepatology،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1130878
Modern Language Association (MLA)
Xu, Wen-xiong…[et al.]. 48-Week Outcome after Cessation of Nucleos(t)ide Analogue Treatment in Chronic Hepatitis B Patient and the Associated Factors with Relapse. Canadian Journal of Gastroenterology and Hepatology No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1130878
American Medical Association (AMA)
Xu, Wen-xiong& Zhang, Qian& Xiang, Zhu& Lin, Chao-shuang& Chen, You-ming& Deng, Hong…[et al.]. 48-Week Outcome after Cessation of Nucleos(t)ide Analogue Treatment in Chronic Hepatitis B Patient and the Associated Factors with Relapse. Canadian Journal of Gastroenterology and Hepatology. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1130878
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130878