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A Critical Review of the Evidence Concerning the HIV Latency Reversing Effect of Disulfiram, the Possible Explanations for Its Inability to Reduce the Size of the Latent Reservoir In Vivo, and the Caveats Associated with Its Use in Practice
Author
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Combination antiretroviral therapy (cART) effectively suppresses the replication of human immunodeficiency virus type 1 (HIV-1), improves immune function, and decreases the morbidity of acquired immune deficiency syndrome (AIDS).
However, it is unable to eradicate the virus because it does not eliminate latently infected cells.
The latent reservoir poses the major barrier to an HIV-1 cure.
The “shock and kill” strategy aims to reactivate the virus and destroy latently infected cells.
Many latency reversing agents (LRAs) reactivate HIV in vitro, but the absence of damaging side-effects and efficacy in vivo make disulfiram particularly promising.
However, in clinical trials to date, disulfiram treatment has not resulted in a reduction in the size of the latent reservoir.
In this article I will therefore discuss the evidence for the latency reversing effect of disulfiram, the possible explanations for its inability to reduce the size of the latent reservoir in vivo, and the caveats associated with its use in practice.
These considerations will help to inform judgements about the prospect of an HIV cure from disulfiram based treatments.
American Psychological Association (APA)
Knights, Harry D. J.. 2017. A Critical Review of the Evidence Concerning the HIV Latency Reversing Effect of Disulfiram, the Possible Explanations for Its Inability to Reduce the Size of the Latent Reservoir In Vivo, and the Caveats Associated with Its Use in Practice. AIDS Research and Treatment،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1130957
Modern Language Association (MLA)
Knights, Harry D. J.. A Critical Review of the Evidence Concerning the HIV Latency Reversing Effect of Disulfiram, the Possible Explanations for Its Inability to Reduce the Size of the Latent Reservoir In Vivo, and the Caveats Associated with Its Use in Practice. AIDS Research and Treatment No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1130957
American Medical Association (AMA)
Knights, Harry D. J.. A Critical Review of the Evidence Concerning the HIV Latency Reversing Effect of Disulfiram, the Possible Explanations for Its Inability to Reduce the Size of the Latent Reservoir In Vivo, and the Caveats Associated with Its Use in Practice. AIDS Research and Treatment. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1130957
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130957