The Molecular Basis and Therapeutic Potential of Let-7 MicroRNAs against Colorectal Cancer

Joint Authors

Kawada, Kenji
Mizuno, Rei
Sakai, Yoshiharu

Source

Canadian Journal of Gastroenterology and Hepatology

Issue

Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2018-06-19

Country of Publication

Egypt

No. of Pages

7

Main Subjects

Diseases
Medicine

Abstract EN

Although a number of studies have revealed the underlying mechanisms which regulate the development of colorectal cancer (CRC), we have not completely overcome this disease yet.

Accumulating evidence has shown that the posttranscriptional regulation by the noncoding RNAs such as microRNAs plays an important role in the development or progression of CRC.

Among a number of microRNAs, the let-7 microRNA family that was first discovered in C.

elegans and conserved from worms to humans has been linked with the development of many types of cancers including CRC.

The expression level of let-7 microRNAs is temporally low during the normal developmental processes, while elevated in the differentiated tissues.

The let-7 microRNAs regulate the cell proliferation, cell cycle, apoptosis, metabolism, and stemness.

In CRC, expressions of let-7 microRNAs have been reported to be reduced, and so let-7 microRNAs are considered to be a tumor suppressor.

In this review, we discuss the mechanisms regulating the let-7 microRNA expression and the downstream targets of let-7 in the context of intestinal tumorigenesis.

The application of let-7 mimics is also highlighted as a novel therapeutic agent.

American Psychological Association (APA)

Mizuno, Rei& Kawada, Kenji& Sakai, Yoshiharu. 2018. The Molecular Basis and Therapeutic Potential of Let-7 MicroRNAs against Colorectal Cancer. Canadian Journal of Gastroenterology and Hepatology،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1130969

Modern Language Association (MLA)

Mizuno, Rei…[et al.]. The Molecular Basis and Therapeutic Potential of Let-7 MicroRNAs against Colorectal Cancer. Canadian Journal of Gastroenterology and Hepatology No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1130969

American Medical Association (AMA)

Mizuno, Rei& Kawada, Kenji& Sakai, Yoshiharu. The Molecular Basis and Therapeutic Potential of Let-7 MicroRNAs against Colorectal Cancer. Canadian Journal of Gastroenterology and Hepatology. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1130969

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1130969