Immunohistochemical Coexpression of Epithelial Cell Adhesion Molecule and Alpha-Fetoprotein in Hepatocellular Carcinoma
Joint Authors
Lima, Leonardo do Prado
Machado, Carla Jorge
Rodrigues, João Bernardo Sancio Rocha
Vasconcellos, Leonardo de Souza
Junior, Eduardo Paulino
Vidigal, Paula Vieira Teixeira
Resende, Vivian
Source
Canadian Journal of Gastroenterology and Hepatology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background and Aim.
The epithelial cell adhesion molecule (EpCAM) has been proposed as a marker for cancer stem cells in human hepatocellular carcinoma (HCC) as well as in the development of novel target therapies.
This study aimed to investigate the immunohistochemical expression of EpCAM and alpha-fetoprotein (AFP) in HCC patients and their association with clinicopathological characteristics.
Methods.
This study included Child-Pugh A HCC patients undergoing curative surgical resection.
Results.
A significant difference was observed in the ratio between the different phenotypes (p = 0.002), identifying 12 (29.3%) EPCAM positive tumors and 29 (70.7%) negative tumors.
EpCAM+ expression was associated with AFP + (OR = 12.5, 95% CI, 1.9-84.1, p<0.001).
In univariate analysis, a significant association was observed between AFP+ and EPCAM+ and the serum AFP level.
A diameter of ≤ 5 cm was associated with EPCAM+, while angiolymphatic invasion was associated with APF+.
In a multivariate analysis, only tumors of ≤ 5 cm were significantly associated with EpCAM+ (OR = 8.7; 95%CI, 1.27-100.0; p = 0.022).
The overall survival rate was 74.9%, 69.4%, 69.4%, and 53.5% at 12, 24, 36, and 48 months, respectively.
Conclusion.
A considerable number of patients with EpCAM+ HCC would benefit from a specific target therapy.
American Psychological Association (APA)
Lima, Leonardo do Prado& Machado, Carla Jorge& Rodrigues, João Bernardo Sancio Rocha& Vasconcellos, Leonardo de Souza& Junior, Eduardo Paulino& Vidigal, Paula Vieira Teixeira…[et al.]. 2018. Immunohistochemical Coexpression of Epithelial Cell Adhesion Molecule and Alpha-Fetoprotein in Hepatocellular Carcinoma. Canadian Journal of Gastroenterology and Hepatology،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1130979
Modern Language Association (MLA)
Lima, Leonardo do Prado…[et al.]. Immunohistochemical Coexpression of Epithelial Cell Adhesion Molecule and Alpha-Fetoprotein in Hepatocellular Carcinoma. Canadian Journal of Gastroenterology and Hepatology No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1130979
American Medical Association (AMA)
Lima, Leonardo do Prado& Machado, Carla Jorge& Rodrigues, João Bernardo Sancio Rocha& Vasconcellos, Leonardo de Souza& Junior, Eduardo Paulino& Vidigal, Paula Vieira Teixeira…[et al.]. Immunohistochemical Coexpression of Epithelial Cell Adhesion Molecule and Alpha-Fetoprotein in Hepatocellular Carcinoma. Canadian Journal of Gastroenterology and Hepatology. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1130979
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130979