Excessive Pretreatment Weight Loss Is a Risk Factor for the Survival Outcome of Esophageal Carcinoma Patients Undergoing Radical Surgery and Postoperative Adjuvant Chemotherapy
Joint Authors
Yu, Xiao-Li
Yang, Jin
Chen, Ting
Liu, Yi-min
Xue, Wei-ping
Wang, Ming-Hui
Bai, Shou-Min
Source
Canadian Journal of Gastroenterology and Hepatology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
The prognostic values of weight loss and body mass index (BMI) in esophageal carcinoma remain controversial.
This study aimed to evaluate the impacts of weight loss on the survival of patients undergoing radical surgery and adjuvant chemotherapy.
Methods.
The medical records of 189 consecutive patients with nonmetastatic esophageal carcinoma treated in our hospital between January 2012 and December 2013 were reviewed, and 121 patients were included for analysis.
Results.
Kaplan-Meier analysis revealed that the 3-year overall survival rate was significantly higher in the low pretreatment weight loss (pre-LWL) group than in the high pretreatment weight loss (pre-HWL) group (P<0.001).
In addition, the 3-year overall survival rate of normal weight group was higher than that of overweight and underweight groups (P=0.007).
Multivariate Cox proportional hazards analysis showed that pre-LWL group had a significantly better 3-year overall survival than pre-HWL group (P=0.027, HR = 1.89, and 95% CI = 1.07–3.32).
pN stage and age were also the survival prognostic factors.
Conclusions.
Our study showed that low pretreatment weight loss predicted a better survival outcome in the esophageal carcinoma patients with radical surgery and adjuvant chemotherapy.
However, BMI and weight loss during treatment had no impact on the survival outcome.
American Psychological Association (APA)
Yu, Xiao-Li& Yang, Jin& Chen, Ting& Liu, Yi-min& Xue, Wei-ping& Wang, Ming-Hui…[et al.]. 2018. Excessive Pretreatment Weight Loss Is a Risk Factor for the Survival Outcome of Esophageal Carcinoma Patients Undergoing Radical Surgery and Postoperative Adjuvant Chemotherapy. Canadian Journal of Gastroenterology and Hepatology،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1130983
Modern Language Association (MLA)
Yu, Xiao-Li…[et al.]. Excessive Pretreatment Weight Loss Is a Risk Factor for the Survival Outcome of Esophageal Carcinoma Patients Undergoing Radical Surgery and Postoperative Adjuvant Chemotherapy. Canadian Journal of Gastroenterology and Hepatology No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1130983
American Medical Association (AMA)
Yu, Xiao-Li& Yang, Jin& Chen, Ting& Liu, Yi-min& Xue, Wei-ping& Wang, Ming-Hui…[et al.]. Excessive Pretreatment Weight Loss Is a Risk Factor for the Survival Outcome of Esophageal Carcinoma Patients Undergoing Radical Surgery and Postoperative Adjuvant Chemotherapy. Canadian Journal of Gastroenterology and Hepatology. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1130983
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130983