The Ethanol Supernatant Extracts of Liushenwan Could Alleviate Nanodiethylnitrosamine-Induced Liver Cancer in Mice
Joint Authors
Shang, Hongcai
Li, Yu-Sang
Tang, He-Bin
Chen, Xi-Zhen
Zhang, Wei Kevin
Li, Xiao-Jun
Tian, Guihua
Source
Canadian Journal of Gastroenterology and Hepatology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-26
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Liver cancer is one of the leading causes of cancerous deaths worldwide.
At present, the treatment of hepatocellular carcinoma (HCC) remains to be a problem globally.
Liushenwan (LSW), an ancient Chinese medicine previously used to treat localized infections, was recently reported to possess anticancer activity.
Here in this study, we aim to examine the effect of LSW-ET (LSW-ET is the supernatant fraction of LSW from ultrasound assisted ethanol extraction) in prevention and treatment on nanodiethylnitrosamine- (nanoDEN-) induced HCC in mice.
In nanoDEN-induced HCC mice treated with LSW-ET by oral (po) or intragastric gavage (ig), we observed an alleviation of serum ALT and AST levels, amelioration in histopathological stainings, and an inhibition in liver tumor growth.
In addition, compared with the nanoDEN group, downregulation of multiple pivotal factors (COX-2, β-catenin, PCNA, and HMGB-1) was observed in LSW-ET-po and LSW-ET-ig groups.
Taken together, the delivery of LSW-ET by oral could be a potential prevention and treatment of liver cancer.
American Psychological Association (APA)
Chen, Xi-Zhen& Zhang, Wei Kevin& Tang, He-Bin& Li, Xiao-Jun& Tian, Guihua& Shang, Hongcai…[et al.]. 2018. The Ethanol Supernatant Extracts of Liushenwan Could Alleviate Nanodiethylnitrosamine-Induced Liver Cancer in Mice. Canadian Journal of Gastroenterology and Hepatology،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1131008
Modern Language Association (MLA)
Chen, Xi-Zhen…[et al.]. The Ethanol Supernatant Extracts of Liushenwan Could Alleviate Nanodiethylnitrosamine-Induced Liver Cancer in Mice. Canadian Journal of Gastroenterology and Hepatology No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1131008
American Medical Association (AMA)
Chen, Xi-Zhen& Zhang, Wei Kevin& Tang, He-Bin& Li, Xiao-Jun& Tian, Guihua& Shang, Hongcai…[et al.]. The Ethanol Supernatant Extracts of Liushenwan Could Alleviate Nanodiethylnitrosamine-Induced Liver Cancer in Mice. Canadian Journal of Gastroenterology and Hepatology. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1131008
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131008