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Immune Condition of Colorectal Cancer Patients Featured by Serum Chemokines and Gene Expressions of CD4+ Cells in Blood
Joint Authors
Kaneko, Shuichi
Komura, Takuya
Yano, Masaaki
Miyake, Akimitsu
Takabatake, Hisashi
Miyazawa, Masaki
Ogawa, Norihiko
Seki, Akihiro
Honda, Masao
Matsui, Shigeyuki
Sakai, Yoshio
Wada, Takashi
Source
Canadian Journal of Gastroenterology and Hepatology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Colorectal cancer (CRC), the most common malignancy worldwide, causes inflammation.
We explored the inflammatory pathophysiology of CRC by assessing the peripheral blood parameters.
Methods.
The differences in gene expression profiles of whole blood cells and cell subpopulations between CRC patients and healthy controls were analyzed using DNA microarray.
Serum cytokine/chemokine concentrations in CRC patients and healthy controls were measured via multiplex detection immunoassays.
In addition, we explored correlations between the expression levels of certain genes of peripheral CD4+ cells and serum chemokine concentrations.
Results.
The gene expression profiles of peripheral CD4+ cells of CRC patients differed from those of healthy controls, but this was not true of CD8+ cells, CD14+ cells, CD15+ cells, or CD19+ cells.
Serum IL-8 and eotaxin-1 levels were significantly elevated in CRC patients, and the levels substantially correlated with the expression levels of certain genes of CD4+ cells.
Interestingly, the relationships between gene expression levels in peripheral CD4+ cells and serum IL-8 and eotaxin-1 levels resembled those of monocytes/macrophages, not T cells.
Conclusions.
Serum IL-8 and eotaxin-1 concentrations increased and were associated with changes in the gene expression of peripheral CD4+ cells in CRC patients.
American Psychological Association (APA)
Komura, Takuya& Yano, Masaaki& Miyake, Akimitsu& Takabatake, Hisashi& Miyazawa, Masaki& Ogawa, Norihiko…[et al.]. 2018. Immune Condition of Colorectal Cancer Patients Featured by Serum Chemokines and Gene Expressions of CD4+ Cells in Blood. Canadian Journal of Gastroenterology and Hepatology،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1131019
Modern Language Association (MLA)
Komura, Takuya…[et al.]. Immune Condition of Colorectal Cancer Patients Featured by Serum Chemokines and Gene Expressions of CD4+ Cells in Blood. Canadian Journal of Gastroenterology and Hepatology No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1131019
American Medical Association (AMA)
Komura, Takuya& Yano, Masaaki& Miyake, Akimitsu& Takabatake, Hisashi& Miyazawa, Masaki& Ogawa, Norihiko…[et al.]. Immune Condition of Colorectal Cancer Patients Featured by Serum Chemokines and Gene Expressions of CD4+ Cells in Blood. Canadian Journal of Gastroenterology and Hepatology. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1131019
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131019