Investigating the Evidence of Behavioral, Cognitive, and Psychiatric Endophenotypes in Autism: A Systematic Review
Joint Authors
Abubakar, Amina
Manji, K. P.
Ruparelia, Kavita
Newton, Charles R.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-05
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Substantial evidence indicates that parents of autistic individuals often display milder forms of autistic traits referred to as the broader autism phenotype (BAP).
To determine if discrete endophenotypes of autism can be identified, we reviewed the literature to assess the evidence of behavioral, cognitive, and psychiatric profiles of the BAP.
A systematic review was conducted using EMBASE, MEDLINE, PsycINFO, PsycEXTRA, and Global Health.
Sixty papers met our inclusion criteria and results are discussed according to the proportion of studies that yield significant deficits per domain.
The behavioral, cognitive, and psychiatric endophenotypes in parents of autistic probands are still not clarified; however, evidence suggests mild social/communication deficits, rigid/aloof personality traits, and pragmatic language difficulties as the most useful sociobehavioral candidate endophenotype traits.
The existence of deficits in the cognitive domain does suggest familial vulnerability for autism.
Furthermore, increased depressed mood and anxiety can also be useful markers; however, findings should be interpreted with caution because of the small number of studies in such heterogeneously broad domains and several methodological limitations.
American Psychological Association (APA)
Ruparelia, Kavita& Manji, K. P.& Abubakar, Amina& Newton, Charles R.. 2017. Investigating the Evidence of Behavioral, Cognitive, and Psychiatric Endophenotypes in Autism: A Systematic Review. Autism Research and Treatment،Vol. 2017, no. 2017, pp.1-17.
https://search.emarefa.net/detail/BIM-1131061
Modern Language Association (MLA)
Ruparelia, Kavita…[et al.]. Investigating the Evidence of Behavioral, Cognitive, and Psychiatric Endophenotypes in Autism: A Systematic Review. Autism Research and Treatment No. 2017 (2017), pp.1-17.
https://search.emarefa.net/detail/BIM-1131061
American Medical Association (AMA)
Ruparelia, Kavita& Manji, K. P.& Abubakar, Amina& Newton, Charles R.. Investigating the Evidence of Behavioral, Cognitive, and Psychiatric Endophenotypes in Autism: A Systematic Review. Autism Research and Treatment. 2017. Vol. 2017, no. 2017, pp.1-17.
https://search.emarefa.net/detail/BIM-1131061
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131061