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Metastatic Colorectal Cancer in the Era of Personalized Medicine: A More Tailored Approach to Systemic Therapy
Joint Authors
Source
Canadian Journal of Gastroenterology and Hepatology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-05
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Colorectal cancer is the second most common malignancy diagnosed in Canada.
Despite declining incidence and mortality rates in recent years, there is still a significant number of cases that are metastatic at presentation.
Fluoropyrimidine-based chemotherapy was the backbone of colorectal cancer treatment, but the addition of irinotecan and oxaliplatin to form combination regimens has significantly improved overall survival.
In the past decade, the development of novel biologic agents including therapies directed against vascular endothelial growth factor and epidermal growth factor receptor has further altered the landscape of metastatic colorectal cancer treatment.
However, clinical trials have demonstrated that not all patients respond to these therapies similarly and consideration must be given to individual patient- and tumor-related factors.
A more tailored and biomarker driven approach to treatment selection can optimize outcomes and avoid unnecessary adverse effects.
In this review article, we offer a comprehensive overview of the panel of clinical- and tumor-associated characteristics that influence treatment decisions in metastatic colorectal cancer and how this sets the foundation for a more personalized treatment strategy in oncology.
American Psychological Association (APA)
Yu, Irene S.& Cheung, Winson Y.. 2018. Metastatic Colorectal Cancer in the Era of Personalized Medicine: A More Tailored Approach to Systemic Therapy. Canadian Journal of Gastroenterology and Hepatology،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1131080
Modern Language Association (MLA)
Yu, Irene S.& Cheung, Winson Y.. Metastatic Colorectal Cancer in the Era of Personalized Medicine: A More Tailored Approach to Systemic Therapy. Canadian Journal of Gastroenterology and Hepatology No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1131080
American Medical Association (AMA)
Yu, Irene S.& Cheung, Winson Y.. Metastatic Colorectal Cancer in the Era of Personalized Medicine: A More Tailored Approach to Systemic Therapy. Canadian Journal of Gastroenterology and Hepatology. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1131080
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131080