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Phage-Displayed Peptides Selected to Bind Envelope Glycoprotein Show Antiviral Activity against Dengue Virus Serotype 2
Joint Authors
De La Guardia, Carolina
Quijada, Mario
Lleonart, Ricardo
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-10
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Dengue virus is a growing public health threat that affects hundreds of million peoples every year and leave huge economic and social damage.
The virus is transmitted by mosquitoes and the incidence of the disease is increasing, among other causes, due to the geographical expansion of the vector’s range and the lack of effectiveness in public health interventions in most prevalent countries.
So far, no highly effective vaccine or antiviral has been developed for this virus.
Here we employed phage display technology to identify peptides able to block the DENV2.
A random peptide library presented in M13 phages was screened with recombinant dengue envelope and its fragment domain III.
After four rounds of panning, several binding peptides were identified, synthesized, and tested against the virus.
Three peptides were able to block the infectivity of the virus while not being toxic to the target cells.
Blind docking simulations were done to investigate the possible mode of binding, showing that all peptides appear to bind domain III of the protein and may be mostly stabilized by hydrophobic interactions.
These results are relevant to the development of novel therapeutics against this important virus.
American Psychological Association (APA)
De La Guardia, Carolina& Quijada, Mario& Lleonart, Ricardo. 2017. Phage-Displayed Peptides Selected to Bind Envelope Glycoprotein Show Antiviral Activity against Dengue Virus Serotype 2. Advances in Virology،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1131085
Modern Language Association (MLA)
De La Guardia, Carolina…[et al.]. Phage-Displayed Peptides Selected to Bind Envelope Glycoprotein Show Antiviral Activity against Dengue Virus Serotype 2. Advances in Virology No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1131085
American Medical Association (AMA)
De La Guardia, Carolina& Quijada, Mario& Lleonart, Ricardo. Phage-Displayed Peptides Selected to Bind Envelope Glycoprotein Show Antiviral Activity against Dengue Virus Serotype 2. Advances in Virology. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1131085
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131085