The New Era of Transplant Oncology: Liver Transplantation for Nonresectable Colorectal Cancer Liver Metastases
Joint Authors
McGilvray, Ian D.
Gorgen, Andre
Muaddi, Hala
Zhang, Wei
Gallinger, Steven
Sapisochin, Gonzalo
Source
Canadian Journal of Gastroenterology and Hepatology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Colorectal cancer (CRC) is the third most incident cancer worldwide.
Most of CRC patients will develop distant metastases, mainly to the liver, and liver resection is the only potential chance for cure.
On the other hand, only a small proportion of patients with hepatic CRC metastasis are candidates for upfront liver resection.
Liver transplantation (LT) is an attractive option for patients with nonresectable CRC liver metastases (NRCLM) without extrahepatic involvement.
Initial experiences with LT for NRCLM achieved very poor outcomes, with a 5-year overall survival (OS) lower than 20%.
However, these initial studies did not have a standardized patient selection or neoadjuvant or adjuvant therapies.
With recent advances in the surgical and medical oncology fields, the landscape has changed.
Recent studies from Norway have shown an encouraging 5-year OS of 50% when transplanting patients with NRCLM.
Nevertheless, the main concern when expanding the indications for LT is organ shortage.
To manage this organ shortage, strategies utilizing live donor liver transplantation are gaining favor.
A few ongoing trials are assessing the impact of LT in NRCLM patient survival.
Therefore, the aim of this paper is to review the current status of LT for NRCLM.
American Psychological Association (APA)
Gorgen, Andre& Muaddi, Hala& Zhang, Wei& McGilvray, Ian D.& Gallinger, Steven& Sapisochin, Gonzalo. 2018. The New Era of Transplant Oncology: Liver Transplantation for Nonresectable Colorectal Cancer Liver Metastases. Canadian Journal of Gastroenterology and Hepatology،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1131088
Modern Language Association (MLA)
Gorgen, Andre…[et al.]. The New Era of Transplant Oncology: Liver Transplantation for Nonresectable Colorectal Cancer Liver Metastases. Canadian Journal of Gastroenterology and Hepatology No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1131088
American Medical Association (AMA)
Gorgen, Andre& Muaddi, Hala& Zhang, Wei& McGilvray, Ian D.& Gallinger, Steven& Sapisochin, Gonzalo. The New Era of Transplant Oncology: Liver Transplantation for Nonresectable Colorectal Cancer Liver Metastases. Canadian Journal of Gastroenterology and Hepatology. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1131088
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131088