Synthesis and Cytotoxic Evaluation of Steroidal Copper (Cu (II)) Complexes
Joint Authors
Huang, Yanmin
Gan, Chunfang
Liu, Zhiping
Cui, Jianguo
Kong, Erbin
Zhan, Junyan
Chen, Shuang
Pang, Liping
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Using estrone and pregnenolone as starting materials, some steroidal copper complexes were synthesized by the condensation of steroidal ketones with thiosemicarbazide or diazanyl pyridine and then complexation of steroidal thiosemicarbazones or steroidal diazanyl pyridines with Cu (II).
The complexes were characterized by IR, NMR, and HRMS.
The synthesized compounds were screened for their cytotoxicity against HeLa, Bel-7404, and 293T cell lines in vitro.
The results show that all steroidal copper (II) complexes display obvious antiproliferative activity against the tested cancer cells.
The IC50 values of complexes 5 and 12 against Bel-7404 (human liver carcinoma) are 5.0 and 7.0 μM.
American Psychological Association (APA)
Huang, Yanmin& Kong, Erbin& Zhan, Junyan& Chen, Shuang& Gan, Chunfang& Liu, Zhiping…[et al.]. 2017. Synthesis and Cytotoxic Evaluation of Steroidal Copper (Cu (II)) Complexes. Bioinorganic Chemistry and Applications،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1131134
Modern Language Association (MLA)
Huang, Yanmin…[et al.]. Synthesis and Cytotoxic Evaluation of Steroidal Copper (Cu (II)) Complexes. Bioinorganic Chemistry and Applications No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1131134
American Medical Association (AMA)
Huang, Yanmin& Kong, Erbin& Zhan, Junyan& Chen, Shuang& Gan, Chunfang& Liu, Zhiping…[et al.]. Synthesis and Cytotoxic Evaluation of Steroidal Copper (Cu (II)) Complexes. Bioinorganic Chemistry and Applications. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1131134
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131134