Influence of the Number of Axial Bexarotene Ligands on the Cytotoxicity of Pt(IV) Analogs of Oxaliplatin
Joint Authors
Nosova, Yulia N.
Zenin, Ilia V.
Maximova, Varvara P.
Zhidkova, Ekaterina M.
Kirsanov, Kirill I.
Lesovaya, Ekaterina A.
Lobas, Anna A.
Gorshkov, Mikhail V.
Kovaleva, Olga N.
Galanski, Markus
Keppler, Bernhard K.
Nazarov, Alexey A.
Milaeva, E. R.
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-19
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
We present the synthesis and cytotoxic potencies of new Pt(IV) complexes with bexarotene, an anticancer drug that induces cell differentiation and apoptosis via selective activation of retinoid X receptors.
In these complexes bexarotene is positioned as an axial ligand.
The complex of one bexarotene ligand attached to Pt(IV) oxaliplatin moiety was potent whereas its counterpart carrying two bexarotene ligands was inactive.
American Psychological Association (APA)
Nosova, Yulia N.& Zenin, Ilia V.& Maximova, Varvara P.& Zhidkova, Ekaterina M.& Kirsanov, Kirill I.& Lesovaya, Ekaterina A.…[et al.]. 2017. Influence of the Number of Axial Bexarotene Ligands on the Cytotoxicity of Pt(IV) Analogs of Oxaliplatin. Bioinorganic Chemistry and Applications،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1131142
Modern Language Association (MLA)
Nosova, Yulia N.…[et al.]. Influence of the Number of Axial Bexarotene Ligands on the Cytotoxicity of Pt(IV) Analogs of Oxaliplatin. Bioinorganic Chemistry and Applications No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1131142
American Medical Association (AMA)
Nosova, Yulia N.& Zenin, Ilia V.& Maximova, Varvara P.& Zhidkova, Ekaterina M.& Kirsanov, Kirill I.& Lesovaya, Ekaterina A.…[et al.]. Influence of the Number of Axial Bexarotene Ligands on the Cytotoxicity of Pt(IV) Analogs of Oxaliplatin. Bioinorganic Chemistry and Applications. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1131142
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131142