The Risk Factors of Acquiring Severe Hand, Foot, and Mouth Disease: A Meta-Analysis
Joint Authors
Zhou, Baosen
Sun, Bai Jun
Chen, Hui Jie
Chen, Ye
An, Xiang Dong
Source
Canadian Journal of Infectious Diseases and Medical Microbiology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-26
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Objectives.
The incidence of severe hand, foot, and mouth disease (HFMD) is not low, especially in mainland China in almost every year recently.
In this study, we conducted a meta-analysis to generate large-scale evidence on the risk factors of severe HFMD to provide suggestions on prevention and controlling.
Methods.
PubMed, Web of Science, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), and Wanfang (Chinese) were searched to identify relevant articles.
All analyses were performed using Stata 14.0.
Results.
We conducted a meta-analysis of 11 separate studies.
Fever (odds ratio (OR) 7.396, 95% confidence interval (CI) 3.565–15.342), fever for more than 3 days (OR 5.773, 95% CI 4.199–7.939), vomiting (OR 6.023, 95% CI 2.598–13.963), limb trembling (OR 42.348, 95% CI 11.765–152.437), dyspnea (OR 12.869, 95% CI 1.948–85.017), contact with HFMD children (OR 5.326, 95% CI 1.263–22.466), rashes on the hips (OR 1.650, 95% CI 1.303–2.090), pathologic reflexes (OR 3057.064, 95% CI 494.409–19000), Lethargy (OR 31.791, 95% CI 3.369–300.020), convulsions (OR 23.652, 95% CI 1.973–283.592), and EV71 infection (OR 9.056, 95% CI 4.102–19.996) were significantly related to the risk of severe HFMD.
We did not find an association between female sex (OR 0.918, 95% CI 0.738–1.142), scatter-lived children (OR 1.347, 95% CI 0.245–7.397), floating population (OR 0.847, 95% CI 0.202–3.549), rash on the hands (OR 0.740, 95% CI 0.292–1.874), rash on the foot (OR 0.905, 95% CI 0.645–1.272), the level of the clinic visited first (below the country level) (OR 5.276, 95% CI 0.781–35.630), breast feeding (OR 0.523, 95% CI 0.167–1.643), and the risk of severe HFMD.
Conclusions.
Fever, fever for more than 3 days, vomiting, limb trembling, dyspnea, contact with HFMD children, rashes on the hips, pathologic reflexes, lethargy, convulsions, and EV71 infection are risk factors for severe HFMD.
American Psychological Association (APA)
Sun, Bai Jun& Chen, Hui Jie& Chen, Ye& An, Xiang Dong& Zhou, Baosen. 2018. The Risk Factors of Acquiring Severe Hand, Foot, and Mouth Disease: A Meta-Analysis. Canadian Journal of Infectious Diseases and Medical Microbiology،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1131143
Modern Language Association (MLA)
Sun, Bai Jun…[et al.]. The Risk Factors of Acquiring Severe Hand, Foot, and Mouth Disease: A Meta-Analysis. Canadian Journal of Infectious Diseases and Medical Microbiology No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1131143
American Medical Association (AMA)
Sun, Bai Jun& Chen, Hui Jie& Chen, Ye& An, Xiang Dong& Zhou, Baosen. The Risk Factors of Acquiring Severe Hand, Foot, and Mouth Disease: A Meta-Analysis. Canadian Journal of Infectious Diseases and Medical Microbiology. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1131143
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131143