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Synthesis Characterization and Biological Activities of Coordination Compounds of 4-Hydroxy-3-nitro-2H-chromen-2-one and Its Aminoethanoic Acid and Pyrrolidine-2-carboxylic Acid Mixed Ligand Complexes
Joint Authors
Aiyelabola, T. O.
Isabirye, D. A.
Akinkunmi, E. O.
Obuotor, Efere
Olawuni, Idowu
Jordaan, Johan
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-07
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Coordination compounds of 4-hydroxy-3-nitro-2H-chromen-2-one and their mixed ligand complexes with aminoethanoic acid and pyrrolidine-2-carboxylic acid were synthesized by the reaction of Cu(II) and Zn(II) salts in molar ratio 1 : 2 for the coumarin complexes and 1 : 1 : 1 for the mixed ligand complexes, in basic media.
The compounds formed were characterized using infrared, Uv-vis spectrophotometric analyses, mass spectrometry, magnetic susceptibility measurements, and EDX analyses.
It was concluded that 4-hydroxy-3-nitro-2H-chromen-2-one coordinated as a monobasic ligand for all the complexes; it also coordinated via the carbonyl moiety in the case of the Cu(II) mixed ligand complexes.
Similarly it was proposed that the amino acids also coordinated in a bidentate fashion via their amino nitrogen and carboxylate oxygen atoms.
The synthesized compounds were screened for their antimicrobial and cytotoxic activities.
The complexes exhibited marginal antimicrobial activity but good cytotoxic activity.
American Psychological Association (APA)
Aiyelabola, T. O.& Akinkunmi, E. O.& Obuotor, Efere& Olawuni, Idowu& Isabirye, D. A.& Jordaan, Johan. 2017. Synthesis Characterization and Biological Activities of Coordination Compounds of 4-Hydroxy-3-nitro-2H-chromen-2-one and Its Aminoethanoic Acid and Pyrrolidine-2-carboxylic Acid Mixed Ligand Complexes. Bioinorganic Chemistry and Applications،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1131155
Modern Language Association (MLA)
Aiyelabola, T. O.…[et al.]. Synthesis Characterization and Biological Activities of Coordination Compounds of 4-Hydroxy-3-nitro-2H-chromen-2-one and Its Aminoethanoic Acid and Pyrrolidine-2-carboxylic Acid Mixed Ligand Complexes. Bioinorganic Chemistry and Applications No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1131155
American Medical Association (AMA)
Aiyelabola, T. O.& Akinkunmi, E. O.& Obuotor, Efere& Olawuni, Idowu& Isabirye, D. A.& Jordaan, Johan. Synthesis Characterization and Biological Activities of Coordination Compounds of 4-Hydroxy-3-nitro-2H-chromen-2-one and Its Aminoethanoic Acid and Pyrrolidine-2-carboxylic Acid Mixed Ligand Complexes. Bioinorganic Chemistry and Applications. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1131155
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131155