Structure Analysis of Effective Chemical Compounds against Dengue Viruses Isolated from Isatis tinctoria
Joint Authors
Gao, Bo
Zhang, Jianming
Xie, Lianhui
Source
Canadian Journal of Infectious Diseases and Medical Microbiology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-01
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The history of Chinese herb research can be traced back to thousands of years ago, and the abundant knowledge accumulated for these herbs makes them good candidates for developing new natural drugs.
Isatis tinctoria is probably the most well-studied Chinese herb, which has been identified to be effective against dengue fever.
However, the underlying biological mechanisms are still unclear.
In this study, we adopt combined methods of bioactive trace technology and phytochemical extraction and separation, to guide the isolation and purification of the effective chemical constituents on the water-soluble components of aerial parts of Isatis tinctoria.
In addition, we apply polarimetry and 1D or 2D nuclear magnetic resonance (NMR) spectroscopy to identify their structures, which lay a foundation for further study on the biological mechanisms underlying medicinal effects of Isatis tinctoria using in vitro and in vivo experiments.
Specifically, we identify and infer the structures of 27 types of chemical compounds named GB-1, GB-2, …, GB-27, respectively, among which GB-7 is a novel compound.
Further study of these compounds is critical to reveal the secrets behind the medicinal effects of Isatis tinctoria.
American Psychological Association (APA)
Gao, Bo& Zhang, Jianming& Xie, Lianhui. 2018. Structure Analysis of Effective Chemical Compounds against Dengue Viruses Isolated from Isatis tinctoria. Canadian Journal of Infectious Diseases and Medical Microbiology،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1131156
Modern Language Association (MLA)
Gao, Bo…[et al.]. Structure Analysis of Effective Chemical Compounds against Dengue Viruses Isolated from Isatis tinctoria. Canadian Journal of Infectious Diseases and Medical Microbiology No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1131156
American Medical Association (AMA)
Gao, Bo& Zhang, Jianming& Xie, Lianhui. Structure Analysis of Effective Chemical Compounds against Dengue Viruses Isolated from Isatis tinctoria. Canadian Journal of Infectious Diseases and Medical Microbiology. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1131156
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131156