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Immunogenicity and Safety of a Chemically Synthesized Divalent Group A Streptococcal Vaccine
Joint Authors
Wu, Yongxiang
Li, Suhua
Luo, Yanting
Zhao, Yunyue
Wang, Jiarui
Dong, Ruimin
Xie, Xujing
Zhu, Jieming
Liu, Jinlai
Source
Canadian Journal of Infectious Diseases and Medical Microbiology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Group A streptococcus (GAS) infections and poststreptococcal sequelae remain a health problem worldwide, which necessitates searching for an effective vaccine, while no licensed GAS vaccine is available.
We have developed a divalent peptide vaccine composed of 84 amino acids to cover the main GAS serotypes (M1 and M12 streptococci) in China, and herein, we aimed to evaluate immunogenicity and safety of this vaccine.
Methods.
Mice were immunized with the vaccine.
ELISA, indirect bactericidal test, and immunofluorescent assay were used to study immunogenicity.
GAS challenge assay was used to test the protective effect.
Safety was tested by histopathological analysis.
Results.
Immunized group mice (n=16) developed higher titer antibody after immunization than nonimmunized group mice (n=16) did.
This antibody can deposit on the surface of GAS and promote killing of GAS, resulting in 93.1% decrease of M1 GAS and 89.5% of M12 GAS.
When challenged with M1 and M12 streptococci, immunized group mice had a higher survival rate (87.5% and 75%) than nonimmunized group mice (37.5% and 25%).
No autoimmune reactions were detected on organs of mice.
Conclusion.
The results suggest that this vaccine shows fair immunogenicity and safety, which will lead our research on GAS vaccine into clinical trial.
American Psychological Association (APA)
Wu, Yongxiang& Li, Suhua& Luo, Yanting& Zhao, Yunyue& Wang, Jiarui& Dong, Ruimin…[et al.]. 2018. Immunogenicity and Safety of a Chemically Synthesized Divalent Group A Streptococcal Vaccine. Canadian Journal of Infectious Diseases and Medical Microbiology،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1131186
Modern Language Association (MLA)
Wu, Yongxiang…[et al.]. Immunogenicity and Safety of a Chemically Synthesized Divalent Group A Streptococcal Vaccine. Canadian Journal of Infectious Diseases and Medical Microbiology No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1131186
American Medical Association (AMA)
Wu, Yongxiang& Li, Suhua& Luo, Yanting& Zhao, Yunyue& Wang, Jiarui& Dong, Ruimin…[et al.]. Immunogenicity and Safety of a Chemically Synthesized Divalent Group A Streptococcal Vaccine. Canadian Journal of Infectious Diseases and Medical Microbiology. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1131186
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131186