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RAPD PCR Profile, Antibiotic Resistance, Prevalence of armA Gene, and Detection of KPC Enzyme in Klebsiella pneumoniae Isolates
Joint Authors
Saadatian Farivar, Arezoo
Nowroozi, Jamileh
Eslami, Gita
Sabokbar, Azar
Source
Canadian Journal of Infectious Diseases and Medical Microbiology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-04
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The increasing prevalence of multidrug-resistant Klebsiella pneumoniae strains isolated from hospitals shows the limitation of recent antibiotics used for bacterial eradication.
In this study, 81 K.
pneumoniae isolates were collected from three hospitals in Tehran.
Antibiotic susceptibility test showed the highest rates of resistance to cefotaxim (85.5%) and ceftazidime (78.3%), and the lowest rates of resistance were detected for colistin (16.9%), streptomycin (16.8%), and chloroamphenicol (21.7%).
Eleven different resistance patterns were observed.
Sixty-six out of 81 isolates (81.5%) were found to be multidrug resistant (MDR), and 35.8% of them belonged to A3 resistance pattern.
7.4% and 66.7% were KPC enzyme and armA gene positive, respectively.
RAPD PCR assay of these bacteria showed 5 clusters, 16 single types, and 14 common types, and there was not any correlation between genetic patterns of the isolates and presence of resistance agents.
Simultaneous detection of resistance-creating agents could be an important challenge for combination therapy of MDR K.
pneumoniae-caused infections.
American Psychological Association (APA)
Saadatian Farivar, Arezoo& Nowroozi, Jamileh& Eslami, Gita& Sabokbar, Azar. 2018. RAPD PCR Profile, Antibiotic Resistance, Prevalence of armA Gene, and Detection of KPC Enzyme in Klebsiella pneumoniae Isolates. Canadian Journal of Infectious Diseases and Medical Microbiology،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1131204
Modern Language Association (MLA)
Saadatian Farivar, Arezoo…[et al.]. RAPD PCR Profile, Antibiotic Resistance, Prevalence of armA Gene, and Detection of KPC Enzyme in Klebsiella pneumoniae Isolates. Canadian Journal of Infectious Diseases and Medical Microbiology No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1131204
American Medical Association (AMA)
Saadatian Farivar, Arezoo& Nowroozi, Jamileh& Eslami, Gita& Sabokbar, Azar. RAPD PCR Profile, Antibiotic Resistance, Prevalence of armA Gene, and Detection of KPC Enzyme in Klebsiella pneumoniae Isolates. Canadian Journal of Infectious Diseases and Medical Microbiology. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1131204
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131204