In Vitro Study of Antiamoebic Activity of Methanol Extracts of Argemone mexicana on Trophozoites of Entamoeba histolytica HM1-IMSS
Joint Authors
Vargas-Villarreal, Javier
Rodríguez-Luis, Osvelia E.
Elizondo-Luévano, Joel H.
Castro-Ríos, Rocío
Sánchez-García, Eduardo
Chávez-Montes, Abelardo
Hernández-García, Magda E.
Source
Canadian Journal of Infectious Diseases and Medical Microbiology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Infections caused by parasites in humans represent one of the main public health concerns.
Amoebiasis, a parasitic infection caused by Entamoeba histolytica (E.
histolytica), is considered endemic in Mexico, where Argemone mexicana (A.
mexicana) has been used in traditional medicine to treat intestinal parasitic diseases.
The objective of this work was to evaluate the potential biological activity of A.
mexicana on E.
histolytica.
For this purpose, a methanolic extract was prepared from A.
mexicana leaves, and a differential fractionation was carried out with solvents of different polarities.
The inhibitory capacities of the extract and its fractions were evaluated in vitro using HM1-IMSS, a strain of Entamoeba histolytica.
A.
mexicana extract was found to have a growth-inhibiting activity for E.
histolytica, showing IC50 = 78.39 μg/mL.
The extract was characterized phytochemically, and the methanolic extract fractions were analyzed by liquid chromatography (HPLC) and mass spectrometry (MS).
Berberine and jatrorrhizine were present in the active fractions, and these compounds may be responsible for the antiparasitic activity.
The identification of amoebicidal activity of A.
mexicana on E.
histolytica gives support to the traditional use.
Further studies with berberine and jatrorrhizine will be carried out to understand the mechanism involved.
American Psychological Association (APA)
Elizondo-Luévano, Joel H.& Castro-Ríos, Rocío& Sánchez-García, Eduardo& Hernández-García, Magda E.& Vargas-Villarreal, Javier& Rodríguez-Luis, Osvelia E.…[et al.]. 2018. In Vitro Study of Antiamoebic Activity of Methanol Extracts of Argemone mexicana on Trophozoites of Entamoeba histolytica HM1-IMSS. Canadian Journal of Infectious Diseases and Medical Microbiology،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1131231
Modern Language Association (MLA)
Elizondo-Luévano, Joel H.…[et al.]. In Vitro Study of Antiamoebic Activity of Methanol Extracts of Argemone mexicana on Trophozoites of Entamoeba histolytica HM1-IMSS. Canadian Journal of Infectious Diseases and Medical Microbiology No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1131231
American Medical Association (AMA)
Elizondo-Luévano, Joel H.& Castro-Ríos, Rocío& Sánchez-García, Eduardo& Hernández-García, Magda E.& Vargas-Villarreal, Javier& Rodríguez-Luis, Osvelia E.…[et al.]. In Vitro Study of Antiamoebic Activity of Methanol Extracts of Argemone mexicana on Trophozoites of Entamoeba histolytica HM1-IMSS. Canadian Journal of Infectious Diseases and Medical Microbiology. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1131231
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131231