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Catheter-Associated Urinary Tract Infection and Obstinate Biofilm Producers
Joint Authors
Maharjan, Govinda
Khadka, Priyatam
Siddhi Shilpakar, Gomik
Chapagain, Ganesh
Dhungana, Guna Raj
Source
Canadian Journal of Infectious Diseases and Medical Microbiology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Biofilms, or colonies of uropathogen growing on the surface of indwelling medical devices, can inflict obstinate or recurring infection, thought-provoking antimicrobial therapy.
Methods.
This prospective analysis included 105 urine samples from catheterized patients receiving intensive care.
Ensuing phenotypic identification, antibiotic sensitivity test was performed by modified Kirby–Bauer disc diffusion method following CLSI guidelines; MDR isolates were identified according to the combined guidelines of the European Centre for Disease Prevention and Control (ECDC) and the Centers for Disease Control and Prevention (CDC).
Biofilm-forming uropathogens were detected by the tissue culture plate (TCA) method.
Results.
The predominant uropathogen in catheter-associated UTIs (CAUTIs) was Escherichia coli 57%, followed by Klebsiella pneumonia 15%, Pseudomonas aeruginosa 12%, Staphylococcus aureus 8%, Enterobacter spp.
3%, Enterococcus faecalis, Acinetobacter spp., and Proteus mirabilis 1.5%, of which 46% isolates were biofilm producers.
Prime biofilm producers were Escherichia coli 33%, followed by Klebsiella pneumoniae 30%, Pseudomonas aeruginosa 20%, Staphylococcus aureus 10%, Acinetobacter, and Enterobacter 3.33%.
Multidrug resistance associated with biofilm producers were greater than biofilm nonproducers.
The Gram-negative biofilm producers found 96.15%, 80.76%, 73.07%, 53.84%, 53.84%, 46.15%, 19.23%, and 11.5% resistant to amoxyclave, ceftazidime, tetracycline, gentamicin, meropenem, nitrofurantoin, amikacin, imipenem, and fosfomycin, respectively.
Gram-positive biofilm producers, however, were found 100% resistant to tetracycline, cloxacillin, and amoxyclave: 66.67% resistant to ampicillin while 33.33% resistant to gentamicin, ciprofloxacin, and nitrofurantoin.
Conclusion.
High antimicrobial resistance was observed in biofilm producers than non-biofilm producers.
Of recommended antimicrobial therapies for CAUTIs, ampicillin and amoxicillin-clavulanate were the least active antibiotics, whereas piperacillin/tazobactam and imipenem were found as the most effectual for gram-negative biofilm producer.
Likewise, amoxicillin-clavulanate and tetracycline were the least active antibiotics, whereas vancomycin, fosfomycin, piperacillin-tazobactam, and meropenem were found as the most effective antibiotic for Gram-positive biofilm producer.
In the limelight, the activity fosfomycin was commendable against both Gram-positive and Gram-negative biofilm producers.
American Psychological Association (APA)
Maharjan, Govinda& Khadka, Priyatam& Siddhi Shilpakar, Gomik& Chapagain, Ganesh& Dhungana, Guna Raj. 2018. Catheter-Associated Urinary Tract Infection and Obstinate Biofilm Producers. Canadian Journal of Infectious Diseases and Medical Microbiology،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1131234
Modern Language Association (MLA)
Maharjan, Govinda…[et al.]. Catheter-Associated Urinary Tract Infection and Obstinate Biofilm Producers. Canadian Journal of Infectious Diseases and Medical Microbiology No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1131234
American Medical Association (AMA)
Maharjan, Govinda& Khadka, Priyatam& Siddhi Shilpakar, Gomik& Chapagain, Ganesh& Dhungana, Guna Raj. Catheter-Associated Urinary Tract Infection and Obstinate Biofilm Producers. Canadian Journal of Infectious Diseases and Medical Microbiology. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1131234
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131234