Do the Th17 Cells Play a Role in the Pathogenesis of Leptospirosis?
Joint Authors
Bandara, Kanchana
Gunasekara, Chinthika
Weerasekera, Manjula
Marasinghe, Chamil
Ranasinghe, Nilantha
Fernando, Neluka
Source
Canadian Journal of Infectious Diseases and Medical Microbiology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-10
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Objectives.
The aim of this study was to determine the level of five different pro- and anti-inflammatory cytokines to study the inflammatory response of leptospirosis.
Materials and methods.
The serum cytokine levels of IL-10, IL-17A, IL-21, IL-23, and TNF-α were investigated in 57 patients with leptospirosis and 12 healthy controls using a commercially available ELISA kit (Mabtech, Sweden).
Statistical analysis was done using Graphpad Prism.
Results.
Elevation of serum IL-10 and IL-17A levels and significant elevation of serum IL-21 (p=0.002), IL-23 (p=0.002), and TNF-α (p=0.039) were observed among leptospirosis patients compared to the healthy control group.
The two major complications observed among these patients were renal failure and liver involvement.
Renal failure was significantly associated with elevation of IL-21 and IL-23, while patients with liver involvement had a significant elevation of IL-21, IL-23, and TNF-α.
Conclusion.
Elevation of IL-17A together with the significant elevation of IL-21 and IL-23 suggests a possible involvement of Th17 cells in the immunopathogenesis of leptospirosis.
American Psychological Association (APA)
Bandara, Kanchana& Gunasekara, Chinthika& Weerasekera, Manjula& Marasinghe, Chamil& Ranasinghe, Nilantha& Fernando, Neluka. 2018. Do the Th17 Cells Play a Role in the Pathogenesis of Leptospirosis?. Canadian Journal of Infectious Diseases and Medical Microbiology،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1131256
Modern Language Association (MLA)
Bandara, Kanchana…[et al.]. Do the Th17 Cells Play a Role in the Pathogenesis of Leptospirosis?. Canadian Journal of Infectious Diseases and Medical Microbiology No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1131256
American Medical Association (AMA)
Bandara, Kanchana& Gunasekara, Chinthika& Weerasekera, Manjula& Marasinghe, Chamil& Ranasinghe, Nilantha& Fernando, Neluka. Do the Th17 Cells Play a Role in the Pathogenesis of Leptospirosis?. Canadian Journal of Infectious Diseases and Medical Microbiology. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1131256
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131256