Influence of Molecular Mobility on Contrast Efficiency of Branched Polyethylene Glycol Contrast Agent
Joint Authors
Mahara, Atsushi
Yamaoka, Tetsuji
Hsu, Yu-I
Source
Contrast Media & Molecular Imaging
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
For a water-soluble polyethylene glycol (PEG) magnetic resonance imaging (MRI) contrast agent, it has been demonstrated that the contrast efficiency was increased with increased branched structure of the contrast agent.
However, the cause of enhanced contrast efficiency by the branched structure has not been clarified.
Hence, we investigate the cause of the contrast agent enhancement by changing the Gd introduction ratio of the eight-arm PEG from 1.97 to 4.07; furthermore, the terminal mobility of the contrast agents with different structures was evaluated using proton nuclear magnetic resonance (1H-NMR) spectroscopy.
It was shown that the relaxivity and contrast luminance of the synthesized branched PEG-Gd contrast agents are larger than those of linear PEG-Gd and commercially available contrast agents.
Additionally, the change in the Gd introduction ratio did not affect the contrast efficiency.
The terminal mobility results measured by NMR show that the linewidth at half height became broader with an increased number of branches, implying that the mobility of branched PEG-Gd is slower than that of linear PEG-Gd.
Interestingly, the linewidth at half height of different structures did not change in an organic solvent; this phenomenon appeared specifically in water.
It is suggested that the stable branched structure enabled the improvement in the relaxivity and contrast luminance.
American Psychological Association (APA)
Hsu, Yu-I& Mahara, Atsushi& Yamaoka, Tetsuji. 2018. Influence of Molecular Mobility on Contrast Efficiency of Branched Polyethylene Glycol Contrast Agent. Contrast Media & Molecular Imaging،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1131281
Modern Language Association (MLA)
Hsu, Yu-I…[et al.]. Influence of Molecular Mobility on Contrast Efficiency of Branched Polyethylene Glycol Contrast Agent. Contrast Media & Molecular Imaging No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1131281
American Medical Association (AMA)
Hsu, Yu-I& Mahara, Atsushi& Yamaoka, Tetsuji. Influence of Molecular Mobility on Contrast Efficiency of Branched Polyethylene Glycol Contrast Agent. Contrast Media & Molecular Imaging. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1131281
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131281