Thin-Shelled PEGylated Perfluorooctyl Bromide Nanocapsules for Tumor-Targeted Ultrasound Contrast Agent
Joint Authors
Tsushima, Yoshito
Achmad, Arifudin
Yamaguchi, Aiko
Hanaoka, Hirofumi
Source
Contrast Media & Molecular Imaging
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-01
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Shell thickness determines the acoustic response of polymer-based perfluorooctyl bromide (PFOB) nanocapsule ultrasound contrast agents.
PEGylation provides stealth property and arms for targeting moieties.
We investigated a modulation in the polymer formulation of carboxy-terminated poly(d,l-lactide-co-glycolide) (PLGA) and poly(d,l-lactide-co-glycolide)-block-polyethylene glycol (PLGA-b-PEG) to produce thin-shelled PFOB nanocapsules while keeping its echogenicity, stealth property, and active targeting potential.
Polymer formulation contains 40% PLGA-PEG that yields the PEGylated PFOB nanocapsules of approximately 150 nm size with average thickness-to-radius ratio down to 0.15, which adequately hindered phagocytosis.
Functionalization with antibody enables in vitro tumor-specific targeting.
Despite the acoustic response improvement, the in vivo tumor accumulation was inadequate to generate an observable acoustic response to the ultrasound power at the clinical level.
The use of PLGA and PLGA-PEG polymer blend allows the production of thin-shelled PFOB nanocapsules with echogenicity improvement while maintaining its potential for specific targeting.
American Psychological Association (APA)
Achmad, Arifudin& Yamaguchi, Aiko& Hanaoka, Hirofumi& Tsushima, Yoshito. 2018. Thin-Shelled PEGylated Perfluorooctyl Bromide Nanocapsules for Tumor-Targeted Ultrasound Contrast Agent. Contrast Media & Molecular Imaging،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1131296
Modern Language Association (MLA)
Achmad, Arifudin…[et al.]. Thin-Shelled PEGylated Perfluorooctyl Bromide Nanocapsules for Tumor-Targeted Ultrasound Contrast Agent. Contrast Media & Molecular Imaging No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1131296
American Medical Association (AMA)
Achmad, Arifudin& Yamaguchi, Aiko& Hanaoka, Hirofumi& Tsushima, Yoshito. Thin-Shelled PEGylated Perfluorooctyl Bromide Nanocapsules for Tumor-Targeted Ultrasound Contrast Agent. Contrast Media & Molecular Imaging. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1131296
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131296