Thallium Labeled Citrate-Coated Prussian Blue Nanoparticles as Potential Imaging Agent

Joint Authors

Varga, Zoltán
Szigeti, Krisztián
Hegedűs, Nikolett
Rácz, Kitti
Horváth, Ildikó
Veres, Dániel S.
Szöllősi, Dávid
Futó, Ildikó
Módos, Károly
Bozó, Tamás
Karlinger, Kinga
Kovács, Noémi
Babos, Magor
Budán, Ferenc
Padmanabhan, Parasuraman
Gulyás, Balázs
Máthé, Domokos

Source

Contrast Media & Molecular Imaging

Issue

Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2018-04-26

Country of Publication

Egypt

No. of Pages

10

Main Subjects

Diseases
Medicine

Abstract EN

Background.

The aim of this study was to develop and characterize a nanoparticle-based image-contrast platform which is biocompatible, chemically stable, and accessible for radiolabeling with 201Tl.

We explored whether this nanoparticle enhanced the T1 signal which might make it an MRI contrast agent as well.

Methods.

The physical properties of citrate-coated Prussian blue nanoparticles (PBNPs) (iron(II);iron(III);octadecacyanide) doped with 201Tl isotope were characterized with atomic force microscopy, dynamic light scattering, and zeta potential measurement.

PBNP biodistribution was determined by using SPECT and MRI following intravenous administration into C57BL6 mice.

Activity concentrations (MBq/cm3) were calculated from the SPECT scans for each dedicated volume of interest (VOI) of liver, kidneys, salivary glands, heart, lungs, and brain.

Results.

PBNP accumulation peaked at 2 hours after injection predominantly in the kidneys and the liver followed by a gradual decrease in activity in later time points.

Conclusion.

We synthetized, characterized, and radiolabeled a Prussian blue-based nanoparticle platform for contrast material applications.

Its in vivo radiochemical stability and biodistribution open up the way for further diagnostic applications.

American Psychological Association (APA)

Szigeti, Krisztián& Hegedűs, Nikolett& Rácz, Kitti& Horváth, Ildikó& Veres, Dániel S.& Szöllősi, Dávid…[et al.]. 2018. Thallium Labeled Citrate-Coated Prussian Blue Nanoparticles as Potential Imaging Agent. Contrast Media & Molecular Imaging،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1131303

Modern Language Association (MLA)

Szigeti, Krisztián…[et al.]. Thallium Labeled Citrate-Coated Prussian Blue Nanoparticles as Potential Imaging Agent. Contrast Media & Molecular Imaging No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1131303

American Medical Association (AMA)

Szigeti, Krisztián& Hegedűs, Nikolett& Rácz, Kitti& Horváth, Ildikó& Veres, Dániel S.& Szöllősi, Dávid…[et al.]. Thallium Labeled Citrate-Coated Prussian Blue Nanoparticles as Potential Imaging Agent. Contrast Media & Molecular Imaging. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1131303

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1131303