PET Imaging of Crossed Cerebellar Diaschisis after Long-Term Cerebral Ischemia in Rats
Joint Authors
Joya, Ana
Padro, Daniel
Gómez-Vallejo, Vanessa
Plaza-García, Sandra
Llop, Jordi
Martín, Abraham
Source
Contrast Media & Molecular Imaging
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-02
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Crossed cerebellar diaschisis (CCD) is a decrease of regional blood flow and metabolism in the cerebellar hemisphere contralateral to the injured brain hemisphere as a common consequence of stroke.
Despite CCD has been detected in patients with stroke using neuroimaging modalities, the evaluation of this phenomenon in rodent models of cerebral ischemia has been scarcely evaluated so far.
Here, we report the in vivo evaluation of CCD after long-term cerebral ischemia in rats using positron emission tomography (PET) imaging with 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG).
Imaging studies were combined with neurological evaluation to assess functional recovery.
In the ischemic territory, imaging studies showed a significant decrease in glucose metabolism followed by a progressive recovery later on.
Conversely, the cerebellum showed a contralateral hypometabolism from days 7 to 14 after reperfusion.
Neurological behavior showed major impaired outcome at day 1 after ischemia followed by a significant recovery of the sensorimotor function from days 7 to 28 after experimental stroke.
Taken together, these results suggest that the degree of CCD after cerebral ischemia might be predictive of neurological recovery.
American Psychological Association (APA)
Joya, Ana& Padro, Daniel& Gómez-Vallejo, Vanessa& Plaza-García, Sandra& Llop, Jordi& Martín, Abraham. 2018. PET Imaging of Crossed Cerebellar Diaschisis after Long-Term Cerebral Ischemia in Rats. Contrast Media & Molecular Imaging،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1131333
Modern Language Association (MLA)
Joya, Ana…[et al.]. PET Imaging of Crossed Cerebellar Diaschisis after Long-Term Cerebral Ischemia in Rats. Contrast Media & Molecular Imaging No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1131333
American Medical Association (AMA)
Joya, Ana& Padro, Daniel& Gómez-Vallejo, Vanessa& Plaza-García, Sandra& Llop, Jordi& Martín, Abraham. PET Imaging of Crossed Cerebellar Diaschisis after Long-Term Cerebral Ischemia in Rats. Contrast Media & Molecular Imaging. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1131333
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131333