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Investigation of Newly Prepared Biodegradable 32P-chromic Phosphate-polylactide-co-glycolide Seeds and Their Therapeutic Response Evaluation for Glioma Brachytherapy
Joint Authors
Shao, Guoqiang
Wang, Yuebing
Liu, Xianzhong
Zhao, Meili
Song, Jinhua
Huang, Peiling
Wang, Feng
Wang, Zizheng
Source
Contrast Media & Molecular Imaging
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-29
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
32P high-dose rate brachytherapy allows high-dose radiation delivery to target lesions with less damage to adjacent tissues.
The early evaluation of its therapeutic effect on tumours is vital for the optimization of treatment regimes.
The most commonly used 32P-CP colloid tends to leak with blind therapeutic area after intratumour injection.
We prepared 32P-chromic phosphate-polylactide-co-glycolide (32P-CP-PLGA) seeds with biodegradable PLGA as a framework and investigated their characteristics in vitro and in vivo.
We also evaluated the therapeutic effect of 32P-CP-PLGA brachytherapy for glioma with the integrin αvβ3-targeted radiotracer 68Ga-3PRGD2.
32P-CP-PLGA seeds (seed group, SG, 185 MBq) and 32P-CP colloid (colloid group, CG, 18.5 MBq) were implanted or injected into human glioma xenografts in nude mice.
Scanning electron microscopy (SEM) of the seeds, micro-SPECT imaging, and biodistribution studies were performed at different time points.
The tumour volume was measured using a caliper, and 68Ga-3PRGD2 micro-PET-CT imaging was performed to evaluate the therapeutic effect after 32P intratumour administration.
The delayed release of 32P-CP was observed with biodegradation of vehicle PLGA.
Intratumoural effective half-life of 32P-CP in the SG (13.3±0.3) d was longer than that in the CG (10.4±0.3) d (P<0.05), with liver appearance in the CG on SPECT.
A radioactivity gradient developed inside the tumour in the SG, as confirmed by micro-SPECT and SEM.
Tumour uptake of 68Ga-3PRGD2 displayed a significant increase on day 0.5 in the SG and decreased earlier (on day 2) than the volume reduction (on day 8).
Thus, 32P-CP-PLGA seeds, controlling the release of entrapped 32P-CP particles, are promising for glioma brachytherapy, and 68Ga-3PRGD2 imaging shows potential for early response evaluation of 32P-CP-PLGA seeds brachytherapy.
American Psychological Association (APA)
Shao, Guoqiang& Wang, Yuebing& Liu, Xianzhong& Zhao, Meili& Song, Jinhua& Huang, Peiling…[et al.]. 2018. Investigation of Newly Prepared Biodegradable 32P-chromic Phosphate-polylactide-co-glycolide Seeds and Their Therapeutic Response Evaluation for Glioma Brachytherapy. Contrast Media & Molecular Imaging،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1131343
Modern Language Association (MLA)
Shao, Guoqiang…[et al.]. Investigation of Newly Prepared Biodegradable 32P-chromic Phosphate-polylactide-co-glycolide Seeds and Their Therapeutic Response Evaluation for Glioma Brachytherapy. Contrast Media & Molecular Imaging No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1131343
American Medical Association (AMA)
Shao, Guoqiang& Wang, Yuebing& Liu, Xianzhong& Zhao, Meili& Song, Jinhua& Huang, Peiling…[et al.]. Investigation of Newly Prepared Biodegradable 32P-chromic Phosphate-polylactide-co-glycolide Seeds and Their Therapeutic Response Evaluation for Glioma Brachytherapy. Contrast Media & Molecular Imaging. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1131343
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131343