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A New High-Performance Gadonanotube-Polymer Hybrid Material for Stem Cell Labeling and Tracking by MRI
Joint Authors
Moghaddam, Sakineh E.
Cabreira-Hansen, Maria da Graça
Willerson, James T.
Perin, Emerson C.
Wilson, Lon J.
Hernández-Rivera, Mayra
Zaibaq, Nicholas G.
Ajala, Afis
Mowlazadeh-Haghighi, Saghar
Muthupillai, Raja
Source
Contrast Media & Molecular Imaging
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
A gentle, rapid method has been developed to introduce a polyacrylic acid (PAA) polymer coating on the surface of gadonanotubes (GNTs) which significantly increases their dispersibility in water without the need of a surfactant.
As a result, the polymer, with its many carboxylic acid groups, coats the surface of the GNTs to form a new GNT-polymer hybrid material (PAA-GNT) which can be highly dispersed in water (ca.
20 mg·mL−1) at physiological pH.
When dispersed in water, the new PAA-GNT material is a powerful MRI contrast agent with an extremely short water proton spin-lattice relaxation time (T1) which results in a T1-weighted relaxivity of 150 mM−1·s−1 per Gd3+ ion at 1.5 T.
Furthermore, the PAA-GNTs have been used to safely label porcine bone-marrow-derived mesenchymal stem cells for magnetic resonance imaging.
The labeled cells display excellent image contrast in phantom imaging experiments, and transmission electron microscopy images of the labeled cells reveal the presence of highly dispersed PAA-GNTs within the cytoplasm with 1014 Gd3+ ions per cell.
American Psychological Association (APA)
Moghaddam, Sakineh E.& Hernández-Rivera, Mayra& Zaibaq, Nicholas G.& Ajala, Afis& Cabreira-Hansen, Maria da Graça& Mowlazadeh-Haghighi, Saghar…[et al.]. 2018. A New High-Performance Gadonanotube-Polymer Hybrid Material for Stem Cell Labeling and Tracking by MRI. Contrast Media & Molecular Imaging،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1131345
Modern Language Association (MLA)
Moghaddam, Sakineh E.…[et al.]. A New High-Performance Gadonanotube-Polymer Hybrid Material for Stem Cell Labeling and Tracking by MRI. Contrast Media & Molecular Imaging No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1131345
American Medical Association (AMA)
Moghaddam, Sakineh E.& Hernández-Rivera, Mayra& Zaibaq, Nicholas G.& Ajala, Afis& Cabreira-Hansen, Maria da Graça& Mowlazadeh-Haghighi, Saghar…[et al.]. A New High-Performance Gadonanotube-Polymer Hybrid Material for Stem Cell Labeling and Tracking by MRI. Contrast Media & Molecular Imaging. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1131345
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131345