Carboxyl of Poly(D,L-lactide-co-glycolide) Nanoparticles of Perfluorooctyl Bromide for Ultrasonic Imaging of Tumor
Joint Authors
Luo, Shengjuan
Ding, Jinsong
Wang, Peiqi
Wang, Zheng
Ma, Xiaoqian
Yang, Cejun
Liang, Qi
Rong, Pengfei
Wang, Wei
Source
Contrast Media & Molecular Imaging
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-07
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Perfluorooctyl bromide (PFOB) enclosed nanoparticles (NPs) as ultrasonic contrasts have shown promising results in the recent years.
However, NPs display poor contrast enhancement in vivo.
In this work, we used the copolymers poly(lactide-co-glycolide) carboxylic acid (PLGA-COOH) and poly(lactide-co- glycolide) poly(ethylene glycol) carboxylic acid (PLGA-PEG-COOH) as a shell to encapsulate PFOB to prepare a nanoultrasonic contrast agent.
The NPs were small and uniform (210.6±2.9 nm with a polydispersity index of 0.129±0.016) with a complete shell nuclear structure under the transmission electron microscopy (TEM).
In vitro, when concentration of NPs was ≥10 mg/ml and clinical diagnostic frequency was ≥9 MHz, NPs produced intensive enhancement of ultrasonic gray-scale signals.
NPs could produce stable and obvious gray enhancement with high mechanical index (MI) (MI > 0.6).
In vivo, the NPs offered good ultrasound enhancement in tumor after more than 24 h and optical imaging also indicated that NPs were mainly located at tumor site.
Subsequent analysis confirmed that large accumulation of fluorescence was observed in the frozen section of the tumor tissue.
All these results caused the conclusion that NPs encapsulated PFOB has achieved tumor-selective imaging in vivo.
American Psychological Association (APA)
Luo, Shengjuan& Ding, Jinsong& Wang, Peiqi& Wang, Zheng& Ma, Xiaoqian& Yang, Cejun…[et al.]. 2018. Carboxyl of Poly(D,L-lactide-co-glycolide) Nanoparticles of Perfluorooctyl Bromide for Ultrasonic Imaging of Tumor. Contrast Media & Molecular Imaging،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1131348
Modern Language Association (MLA)
Luo, Shengjuan…[et al.]. Carboxyl of Poly(D,L-lactide-co-glycolide) Nanoparticles of Perfluorooctyl Bromide for Ultrasonic Imaging of Tumor. Contrast Media & Molecular Imaging No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1131348
American Medical Association (AMA)
Luo, Shengjuan& Ding, Jinsong& Wang, Peiqi& Wang, Zheng& Ma, Xiaoqian& Yang, Cejun…[et al.]. Carboxyl of Poly(D,L-lactide-co-glycolide) Nanoparticles of Perfluorooctyl Bromide for Ultrasonic Imaging of Tumor. Contrast Media & Molecular Imaging. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1131348
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131348