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Presaturation Power Adjusted Pulsed CEST: A Method to Increase Independence of Target CEST Signals
Joint Authors
Honda, Hiroshi
Kikuchi, Kazufumi
Ishimatsu, Keisuke
Zhang, Shanrong
Dimitrov, Ivan E.
Sherry, A. Dean
Takahashi, Masaya
Source
Contrast Media & Molecular Imaging
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-08
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Chemical exchange saturation transfer (CEST) imaging has been demonstrated to discuss the concentration changes of amide proton, glutamate, creatine, or glucose measured at 3.5, 3.0, 2.0, and 1.0–1.2 ppm.
However, these peaks in z-spectra are quite broad and overlap with each other, and thus, the independence of a CEST signal on any specific metabolite is still open to question.
Here, we described whether there was interference among the CEST signals and how these CEST signals behave when the power of the presaturation pulse was changed.
Based on these results, further experiments were designed to investigate a method to increase the independence of the CEST signal in both phantoms and animals.
The result illustrates a clear interference among CEST signals.
A presaturation power adjusted pulsed- (PPAP-) CEST method which was designed based on the exchange rates of the metabolites can be used to remove contributions from other exchanging species in the same sample.
Further, the method was shown to improve the independence of the glutamate signal in vivo in the renal medulla in mice.
The PPAP-CEST method has the potential to increase the independence of any target CEST signals in vivo by choosing the appropriate combination of pulse amplitudes and durations.
American Psychological Association (APA)
Kikuchi, Kazufumi& Ishimatsu, Keisuke& Zhang, Shanrong& Dimitrov, Ivan E.& Honda, Hiroshi& Sherry, A. Dean…[et al.]. 2018. Presaturation Power Adjusted Pulsed CEST: A Method to Increase Independence of Target CEST Signals. Contrast Media & Molecular Imaging،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1131352
Modern Language Association (MLA)
Kikuchi, Kazufumi…[et al.]. Presaturation Power Adjusted Pulsed CEST: A Method to Increase Independence of Target CEST Signals. Contrast Media & Molecular Imaging No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1131352
American Medical Association (AMA)
Kikuchi, Kazufumi& Ishimatsu, Keisuke& Zhang, Shanrong& Dimitrov, Ivan E.& Honda, Hiroshi& Sherry, A. Dean…[et al.]. Presaturation Power Adjusted Pulsed CEST: A Method to Increase Independence of Target CEST Signals. Contrast Media & Molecular Imaging. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1131352
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131352