Isolated Perfused Rat Livers to Quantify the Pharmacokinetics and Concentrations of Gd-BOPTA
Author
Source
Contrast Media & Molecular Imaging
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-11
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
With recent advances in liver imaging, the estimation of liver concentrations is now possible following the injection of hepatobiliary contrast agents and radiotracers.
However, how these images are generated remains partially unknown.
Most experiments that would be helpful to increase this understanding cannot be performed in vivo.
For these reasons, we investigated the liver distribution of the magnetic resonance (MR) contrast agent gadobenate dimeglumine (Gd-BOPTA, MultiHance®, Bracco Imaging) in isolated perfused rat livers (IPRLs).
In IPRL, we developed a new set up that quantifies simultaneously the Gd-BOPTA compartment concentrations and the transfer rates between these compartments.
Concentrations were measured either by MR signal intensity or by count rates when the contrast agent was labelled by [153Gd].
With this experimental model, we show how the Gd-BOPTA hepatocyte concentrations are modified by temperature and liver flow rates.
We define new pharmacokinetic parameters to quantify the canalicular transport of Gd-BOPTA.
Finally, we present how transfer rates generate Gd-BOPTA concentrations in rat liver compartments.
These findings better explain how liver imaging with hepatobiliary radiotracers and contrast agents is generated and improve the image interpretation by clinicians.
American Psychological Association (APA)
Pastor, Catherine M.. 2018. Isolated Perfused Rat Livers to Quantify the Pharmacokinetics and Concentrations of Gd-BOPTA. Contrast Media & Molecular Imaging،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1131379
Modern Language Association (MLA)
Pastor, Catherine M.. Isolated Perfused Rat Livers to Quantify the Pharmacokinetics and Concentrations of Gd-BOPTA. Contrast Media & Molecular Imaging No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1131379
American Medical Association (AMA)
Pastor, Catherine M.. Isolated Perfused Rat Livers to Quantify the Pharmacokinetics and Concentrations of Gd-BOPTA. Contrast Media & Molecular Imaging. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1131379
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131379