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In Vivo and In Vitro Characteristics of Radiolabeled Vesamicol Analogs as the Vesicular Acetylcholine Transporter Imaging Agents
Joint Authors
Source
Contrast Media & Molecular Imaging
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-13
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The vesicular acetylcholine transporter (VAChT), a presynaptic cholinergic neuron marker, is a potential internal molecular target for the development of an imaging agent for early diagnosis of neurodegenerative disorders with cognitive decline such as Alzheimer’s disease (AD).
Since vesamicol has been reported to bind to VAChT with high affinity, many vesamicol analogs have been studied as VAChT imaging agents for the diagnosis of cholinergic neurodeficit disorder.
However, because many vesamicol analogs, as well as vesamicol, bound to sigma receptors (σ1 and σ2) besides VAChT, almost all the vesamicol analogs have been shown to be unsuitable for clinical trials.
In this report, the relationships between the chemical structure and the biological characteristics of these developed vesamicol analogs were investigated, especially the in vitro binding profile and the in vivo regional brain accumulation.
American Psychological Association (APA)
Ogawa, Kazuma& Shiba, Kazuhiro. 2018. In Vivo and In Vitro Characteristics of Radiolabeled Vesamicol Analogs as the Vesicular Acetylcholine Transporter Imaging Agents. Contrast Media & Molecular Imaging،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1131390
Modern Language Association (MLA)
Ogawa, Kazuma& Shiba, Kazuhiro. In Vivo and In Vitro Characteristics of Radiolabeled Vesamicol Analogs as the Vesicular Acetylcholine Transporter Imaging Agents. Contrast Media & Molecular Imaging No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1131390
American Medical Association (AMA)
Ogawa, Kazuma& Shiba, Kazuhiro. In Vivo and In Vitro Characteristics of Radiolabeled Vesamicol Analogs as the Vesicular Acetylcholine Transporter Imaging Agents. Contrast Media & Molecular Imaging. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1131390
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131390