![](/images/graphics-bg.png)
Natural Cinnamaldehyde and Its Derivatives Ameliorate Neuroinflammatory Pathways in Neurodegenerative Diseases
Joint Authors
Hajinejad, Mehrdad
Ghaddaripouri, Maryam
Dabzadeh, Maryam
Forouzanfar, Fatemeh
Sahab-Negah, Sajad
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Neurodegenerative diseases are devastating and incurable disorders characterized by neuronal dysfunction.
The major focus of experimental and clinical studies are conducted on the effects of natural products and their active components on neurodegenerative diseases.
This review will discuss an herbal constituent known as cinnamaldehyde (CA) with the neuroprotective potential to treat neurodegenerative disorders, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD).
Accumulating evidence supports the notion that CA displays neuroprotective effects in AD and PD animal models by modulating neuroinflammation, suppressing oxidative stress, and improving the synaptic connection.
CA exerts these effects through its action on multiple signaling pathways, including TLR4/NF-κB, NLRP3, ERK1/2-MEK, NO, and Nrf2 pathways.
To summarize, CA and its derivatives have been shown to improve pathological changes in AD and PD animal models, which may provide a new therapeutic option for neurodegenerative interventions.
To this end, further experimental and clinical studies are required to prove the neuroprotective effects of CA and its derivatives.
American Psychological Association (APA)
Hajinejad, Mehrdad& Ghaddaripouri, Maryam& Dabzadeh, Maryam& Forouzanfar, Fatemeh& Sahab-Negah, Sajad. 2020. Natural Cinnamaldehyde and Its Derivatives Ameliorate Neuroinflammatory Pathways in Neurodegenerative Diseases. BioMed Research International،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1131396
Modern Language Association (MLA)
Hajinejad, Mehrdad…[et al.]. Natural Cinnamaldehyde and Its Derivatives Ameliorate Neuroinflammatory Pathways in Neurodegenerative Diseases. BioMed Research International No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1131396
American Medical Association (AMA)
Hajinejad, Mehrdad& Ghaddaripouri, Maryam& Dabzadeh, Maryam& Forouzanfar, Fatemeh& Sahab-Negah, Sajad. Natural Cinnamaldehyde and Its Derivatives Ameliorate Neuroinflammatory Pathways in Neurodegenerative Diseases. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1131396
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131396