Perspectives of Molecular Therapy-Targeted Mitochondrial Fission in Hepatocellular Carcinoma

Joint Authors

Zhang, Hanwen
Ye, Yanshuo
Li, Wei

Source

BioMed Research International

Issue

Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2020-12-29

Country of Publication

Egypt

No. of Pages

7

Main Subjects

Medicine

Abstract EN

Current advances of molecular-targeting therapies for hepatocellular carcinoma (HCC) have improved the overall survival significantly, whereas the results still remain unsatisfied.

Recently, much attention has been focused on organelles, such as the mitochondria, to reveal novel strategies to control the cancers.

The mitochondria are vital organelles which supply energy and maintain metabolism in most of the eukaryotic cells.

They not only execute critical bioenergetic and biosynthetic functions but also regulate ROS homeostasis and apoptosis.

Existing in a dynamic equilibrium state, mitochondria constantly undergo the fission and fusion processes in normal situation.

Increasing evidences have showed that mitochondrial fission is highly related to the diseases and cancers.

Distinctive works have proved the significant effects of mitochondrial fission on HCC behaviors and the crosstalks with other molecular pathways.

Here, we provide an overview of the mitochondrial fission and the link with HCC, emphasizing on the underlying molecular pathways and several novel materials that modulate HCC behaviors.

American Psychological Association (APA)

Zhang, Hanwen& Ye, Yanshuo& Li, Wei. 2020. Perspectives of Molecular Therapy-Targeted Mitochondrial Fission in Hepatocellular Carcinoma. BioMed Research International،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1131398

Modern Language Association (MLA)

Zhang, Hanwen…[et al.]. Perspectives of Molecular Therapy-Targeted Mitochondrial Fission in Hepatocellular Carcinoma. BioMed Research International No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1131398

American Medical Association (AMA)

Zhang, Hanwen& Ye, Yanshuo& Li, Wei. Perspectives of Molecular Therapy-Targeted Mitochondrial Fission in Hepatocellular Carcinoma. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1131398

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1131398