Perspectives of Molecular Therapy-Targeted Mitochondrial Fission in Hepatocellular Carcinoma
Joint Authors
Zhang, Hanwen
Ye, Yanshuo
Li, Wei
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Current advances of molecular-targeting therapies for hepatocellular carcinoma (HCC) have improved the overall survival significantly, whereas the results still remain unsatisfied.
Recently, much attention has been focused on organelles, such as the mitochondria, to reveal novel strategies to control the cancers.
The mitochondria are vital organelles which supply energy and maintain metabolism in most of the eukaryotic cells.
They not only execute critical bioenergetic and biosynthetic functions but also regulate ROS homeostasis and apoptosis.
Existing in a dynamic equilibrium state, mitochondria constantly undergo the fission and fusion processes in normal situation.
Increasing evidences have showed that mitochondrial fission is highly related to the diseases and cancers.
Distinctive works have proved the significant effects of mitochondrial fission on HCC behaviors and the crosstalks with other molecular pathways.
Here, we provide an overview of the mitochondrial fission and the link with HCC, emphasizing on the underlying molecular pathways and several novel materials that modulate HCC behaviors.
American Psychological Association (APA)
Zhang, Hanwen& Ye, Yanshuo& Li, Wei. 2020. Perspectives of Molecular Therapy-Targeted Mitochondrial Fission in Hepatocellular Carcinoma. BioMed Research International،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1131398
Modern Language Association (MLA)
Zhang, Hanwen…[et al.]. Perspectives of Molecular Therapy-Targeted Mitochondrial Fission in Hepatocellular Carcinoma. BioMed Research International No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1131398
American Medical Association (AMA)
Zhang, Hanwen& Ye, Yanshuo& Li, Wei. Perspectives of Molecular Therapy-Targeted Mitochondrial Fission in Hepatocellular Carcinoma. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1131398
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131398