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How to Modulate Tumor Hypoxia for Preclinical In Vivo Imaging Research
Joint Authors
De Bruycker, Sven
Vangestel, Christel
Staelens, Steven
Van den Wyngaert, Tim
Stroobants, Sigrid
Source
Contrast Media & Molecular Imaging
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-18
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Tumor hypoxia is related with tumor aggressiveness, chemo- and radiotherapy resistance, and thus a poor clinical outcome.
Therefore, over the past decades, every effort has been made to develop strategies to battle the negative prognostic influence of tumor hypoxia.
For appropriate patient selection and follow-up, noninvasive imaging biomarkers such as positron emission tomography (PET) radiolabeled ligands are unprecedentedly needed.
Importantly, before being able to implement these new therapies and potential biomarkers into the clinical setting, preclinical in vivo validation in adequate animal models is indispensable.
In this review, we provide an overview of the different attempts that have been made to create differential hypoxic in vivo cancer models with a particular focus on their applicability in PET imaging studies.
American Psychological Association (APA)
De Bruycker, Sven& Vangestel, Christel& Staelens, Steven& Van den Wyngaert, Tim& Stroobants, Sigrid. 2018. How to Modulate Tumor Hypoxia for Preclinical In Vivo Imaging Research. Contrast Media & Molecular Imaging،Vol. 2018, no. 2018, pp.1-17.
https://search.emarefa.net/detail/BIM-1131399
Modern Language Association (MLA)
De Bruycker, Sven…[et al.]. How to Modulate Tumor Hypoxia for Preclinical In Vivo Imaging Research. Contrast Media & Molecular Imaging No. 2018 (2018), pp.1-17.
https://search.emarefa.net/detail/BIM-1131399
American Medical Association (AMA)
De Bruycker, Sven& Vangestel, Christel& Staelens, Steven& Van den Wyngaert, Tim& Stroobants, Sigrid. How to Modulate Tumor Hypoxia for Preclinical In Vivo Imaging Research. Contrast Media & Molecular Imaging. 2018. Vol. 2018, no. 2018, pp.1-17.
https://search.emarefa.net/detail/BIM-1131399
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131399