Light-Triggered Radiochemical Synthesis: A Novel 18F-Labelling Strategy Using Photoinducible Click Reaction to Prepare PET Imaging Probes
Joint Authors
Sohn, Myung-Hee
Choi, Ji Hae
Oh, Doori
Kim, In Sun
Kim, Hyeon-Soo
Kim, Minjoo
Kim, Eun-Mi
Lim, Seok Tae
Kim, Dong Hyun
Jeong, Hwan-Jeong
Source
Contrast Media & Molecular Imaging
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Novel probe development for positron emission tomography (PET) is leading to expanding the scope of molecular imaging.
To begin responding to challenges, several biomaterials such as natural products and small molecules, peptides, engineered proteins including affibodies, and antibodies have been used in the development of targeted molecular imaging probes.
To prepare radiotracers, a few bioactive materials are unique challenges to radiolabelling because of their complex structure, poor stability, poor solubility in aqueous or chemical organic solutions, and sensitivity to temperature and nonphysiological pH.
To overcome these challenges, we developed a new radiolabelling strategy based on photoactivated 1,3-dipolar cycloaddition between alkene dipolarophile and tetrazole moiety containing compounds.
Herein, we describe a light-triggered radiochemical synthesis via photoactivated click reaction to prepare 18F-radiolabelled PET tracers using small molecular and RGD peptide.
American Psychological Association (APA)
Choi, Ji Hae& Oh, Doori& Kim, In Sun& Kim, Hyeon-Soo& Kim, Minjoo& Kim, Eun-Mi…[et al.]. 2018. Light-Triggered Radiochemical Synthesis: A Novel 18F-Labelling Strategy Using Photoinducible Click Reaction to Prepare PET Imaging Probes. Contrast Media & Molecular Imaging،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1131402
Modern Language Association (MLA)
Choi, Ji Hae…[et al.]. Light-Triggered Radiochemical Synthesis: A Novel 18F-Labelling Strategy Using Photoinducible Click Reaction to Prepare PET Imaging Probes. Contrast Media & Molecular Imaging No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1131402
American Medical Association (AMA)
Choi, Ji Hae& Oh, Doori& Kim, In Sun& Kim, Hyeon-Soo& Kim, Minjoo& Kim, Eun-Mi…[et al.]. Light-Triggered Radiochemical Synthesis: A Novel 18F-Labelling Strategy Using Photoinducible Click Reaction to Prepare PET Imaging Probes. Contrast Media & Molecular Imaging. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1131402
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131402