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NIRF OpticalPET Dual-Modal Imaging of Hepatocellular Carcinoma Using Heptamethine Carbocyanine Dye
Joint Authors
Zhang, Caiqin
Zhao, Yong
Zhao, Ningning
Tan, Dengxu
Zhang, He
Chen, Xue
Zhang, Hai
An, Jiaze
Shi, Changhong
Li, Mengbin
Source
Contrast Media & Molecular Imaging
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-08
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Combining near-infrared fluorescence (NIRF) and nuclear imaging techniques provides a novel approach for hepatocellular carcinoma (HCC) diagnosis.
Here, we report the synthesis and characteristics of a dual-modality NIRF optical/positron emission tomography (PET) imaging probe using heptamethine carbocyanine dye and verify its feasibility in both nude mice and rabbits with orthotopic xenograft liver cancer.
This dye, MHI-148, is an effective cancer-specific NIRF imaging agent and shows preferential uptake and retention in liver cancer.
The corresponding NIRF imaging intensity reaches 109/cm2 tumor area at 24 h after injection in mice with HCC subcutaneous tumors.
The dye can be further conjugated with radionuclide 68Ga (68Ga-MHI-148) for PET tracing.
We applied the dual-modality methodology toward the detection of HCC in both patient-derived orthotopic xenograft (PDX) models and rabbit orthotopic transplantation models.
NIRF/PET images showed clear tumor delineation after probe injection (MHI-148 and 68Ga-MHI-148).
The tumor-to-muscle (T/M) standardized uptake value (SUV) ratios were obtained from PET at 1 h after injection of 68Ga-MHI-148, which was helpful for effectively capturing small tumors in mice (0.5 cm × 0.3 cm) and rabbits (1.2 cm × 1.8 cm).
This cancer-targeting NIRF/PET dual-modality imaging probe provides a proof of principle for noninvasive detection of deep-tissue tumors in mouse and rabbit and is a promising technique for more accurate and early detection of HCC.
American Psychological Association (APA)
Zhang, Caiqin& Zhao, Yong& Zhao, Ningning& Tan, Dengxu& Zhang, He& Chen, Xue…[et al.]. 2018. NIRF OpticalPET Dual-Modal Imaging of Hepatocellular Carcinoma Using Heptamethine Carbocyanine Dye. Contrast Media & Molecular Imaging،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1131409
Modern Language Association (MLA)
Zhang, Caiqin…[et al.]. NIRF OpticalPET Dual-Modal Imaging of Hepatocellular Carcinoma Using Heptamethine Carbocyanine Dye. Contrast Media & Molecular Imaging No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1131409
American Medical Association (AMA)
Zhang, Caiqin& Zhao, Yong& Zhao, Ningning& Tan, Dengxu& Zhang, He& Chen, Xue…[et al.]. NIRF OpticalPET Dual-Modal Imaging of Hepatocellular Carcinoma Using Heptamethine Carbocyanine Dye. Contrast Media & Molecular Imaging. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1131409
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131409