![](/images/graphics-bg.png)
177Lu-DOTA-HYNIC-Lys(Nal)-Urea-Glu: Biokinetics, Dosimetry, and Evaluation in Patients with Advanced Prostate Cancer
Joint Authors
García-Perez, Osvaldo
Ferro-Flores, Guillermina
Ocampo-García, Blanca
Santos-Cuevas, Clara
Azorín-Vega, Erika
Jiménez-Mancilla, Nallely
Ramírez-Nava, Gerardo
Luna-Gutiérrez, Myrna
Davanzo, Jenny
Soldevilla-Gallardo, Irma
Source
Contrast Media & Molecular Imaging
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-11
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
SPECT/CT images in patients have demonstrated the ability of [99mTc]Tc-EDDA/HYNIC-Lys(Nal)-Urea-Glu ([99mTc]Tc-iPSMA) to detect tumors and metastases of prostate cancer.
Considering that theranostics combines the potential of therapeutic and diagnostic radionuclides in the same molecular probe, the aim of this research was to estimate the biokinetics and dosimetry of 177Lu-DOTA-HYNIC-Lys(Nal)-Urea-Glu (177Lu-iPSMA) in healthy subjects and analyze the response in patients receiving 177Lu-iPSMA therapeutic doses.
177Lu-iPSMA was obtained from lyophilized formulations with radiochemical purities >98%.
Whole-body images from five healthy subjects were acquired at 20 min, 6, 24, 48, and 120 h after 177Lu-iPSMA administration (185 MBq).
The image sequence was used to extrapolate the 177Lu-iPSMA time-activity curves of each organ to adjust the biokinetic model and calculate the total number of disintegrations (N) that occurred in the source regions.
N data were the input for the OLINDA/EXM code to calculate internal radiation doses.
Ten patients (median age: 68 y; range 58–86 y) received from 1 to 4 cycles of 177Lu-iPSMA (3.7 or 7.4 GBq) every 8–10 weeks.
Response was evaluated using the 68Ga-PSMA-ligand-PET/CT or 99mTc-iPSMA-SPECT/CT diagnostic images and serum PSA levels before and after 177Lu-iPSMA treatment.
The blood activity showed a half-life value of 1.1 h for the fast component (T1/2α = ln2/0.614), 9.2 h for the first slow component (T1/2β = ln2/0.075), and 79.6 h for the second slow component (T1/2γ = ln2/0.008).
The average absorbed doses were 0.23, 0.28, 0.88, and 1.17 Gy/GBq for the spleen, liver, kidney, and salivary glands.
A total of 18 cycles were performed in 10 patients.
A PSA decrease and some reduction of the radiotracer uptake (SUV) in tumor lesions occurred in 60% and 70% of the patients, respectively.
177Lu-iPSMA obtained from kit formulations showed high tumor uptake with good response rates in patients.
The results obtained in this study warrant further clinical studies to establish the optimal number of treatment cycles and for evaluating the effect of this therapeutic agent on survival of patients.
American Psychological Association (APA)
Santos-Cuevas, Clara& Ferro-Flores, Guillermina& García-Perez, Osvaldo& Jiménez-Mancilla, Nallely& Ramírez-Nava, Gerardo& Ocampo-García, Blanca…[et al.]. 2018. 177Lu-DOTA-HYNIC-Lys(Nal)-Urea-Glu: Biokinetics, Dosimetry, and Evaluation in Patients with Advanced Prostate Cancer. Contrast Media & Molecular Imaging،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1131427
Modern Language Association (MLA)
Santos-Cuevas, Clara…[et al.]. 177Lu-DOTA-HYNIC-Lys(Nal)-Urea-Glu: Biokinetics, Dosimetry, and Evaluation in Patients with Advanced Prostate Cancer. Contrast Media & Molecular Imaging No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1131427
American Medical Association (AMA)
Santos-Cuevas, Clara& Ferro-Flores, Guillermina& García-Perez, Osvaldo& Jiménez-Mancilla, Nallely& Ramírez-Nava, Gerardo& Ocampo-García, Blanca…[et al.]. 177Lu-DOTA-HYNIC-Lys(Nal)-Urea-Glu: Biokinetics, Dosimetry, and Evaluation in Patients with Advanced Prostate Cancer. Contrast Media & Molecular Imaging. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1131427
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131427