One-Step 18F-Labeling of Estradiol Derivative for PET Imaging of Breast Cancer
Joint Authors
Huang, Hongbo
Li, Ke
Lv, Gaochao
Liu, Guiqing
Zhao, Xueyu
Liu, Qingzhu
Wang, Shanshan
Li, Xi
Qiu, Ling
Lin, Jianguo
Source
Contrast Media & Molecular Imaging
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Positron emission tomography (PET) imaging is a useful method to evaluate in situ estrogen receptor (ER) status for the early diagnosis of breast cancer and optimization of the appropriate treatment strategy.
The 18F-labeled estradiol derivative has been successfully used to clinically assess the ER level of breast cancer.
In order to simplify the radiosynthesis process, one-step 18F-19F isotope exchange reaction was employed for the 18F-fluorination of the tracer of [18F]AmBF3-TEG-ES.
The radiotracer was obtained with the radiochemical yield (RCY) of ~61% and the radiochemical purity (RCP) of >98% within 40 min.
Cell uptake and blocking assays indicated that the tracer could selectively accumulate in the ER-positive human breast cancer cell lines MCF-7 and T47D.
In vivo PET imaging on the MCF-7 tumor-bearing mice showed relatively high tumor uptake (1.4~2.3 %D/g) and tumor/muscle uptake ratio (4~6).
These results indicated that the tracer is a promising PET imaging agent for ER-positive breast cancers.
American Psychological Association (APA)
Huang, Hongbo& Li, Ke& Lv, Gaochao& Liu, Guiqing& Zhao, Xueyu& Liu, Qingzhu…[et al.]. 2018. One-Step 18F-Labeling of Estradiol Derivative for PET Imaging of Breast Cancer. Contrast Media & Molecular Imaging،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1131450
Modern Language Association (MLA)
Huang, Hongbo…[et al.]. One-Step 18F-Labeling of Estradiol Derivative for PET Imaging of Breast Cancer. Contrast Media & Molecular Imaging No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1131450
American Medical Association (AMA)
Huang, Hongbo& Li, Ke& Lv, Gaochao& Liu, Guiqing& Zhao, Xueyu& Liu, Qingzhu…[et al.]. One-Step 18F-Labeling of Estradiol Derivative for PET Imaging of Breast Cancer. Contrast Media & Molecular Imaging. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1131450
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131450