Association between a TCF4 Polymorphism and Susceptibility to Schizophrenia
Joint Authors
Yan, Chunxia
Zhang, Bao
Wen, Xiao Peng
Gao, Jia-Yang
Ma, Pan
Li, Ying
Zhang, Qian
Yang, Xi-Xi
Shi, Qiang
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-21
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The basic helix-loop-helix (bHLH) transcription factor 4 (TCF4) had been identified as a susceptibility gene associated with schizophrenia (SCZ) by GWAS, but inconsistent results have been found in other studies.
To validate these findings and to reveal the effects of different inheritance models, rs2958182, rs1261085, rs8766, and rs12966547 of the TCF4 gene were genotyped in the Northwest Han Chinese population (448 cases and 628 controls) via a multiplex polymerase chain reaction SNPscan assay.
Single SNP, genotype, and association analyses with three different models were performed.
We observed genotype and allele distributions of four SNPs that showed nonsignificant associations in the Northwest Han Chinese population.
However, published datasets (51,892 cases and 68,498 controls) were collected and combined with our experimental results to ascertain the association of the TCF4 gene SNPs and SCZ, which demonstrated that rs2958182 (P=0.003) was a significant signal based on a systematic meta-analysis.
To clarify the biological role of rs2958182, it is important to improve the understanding of the pathophysiology of SCZ.
American Psychological Association (APA)
Gao, Jia-Yang& Ma, Pan& Li, Ying& Yan, Chunxia& Zhang, Qian& Yang, Xi-Xi…[et al.]. 2020. Association between a TCF4 Polymorphism and Susceptibility to Schizophrenia. BioMed Research International،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1131462
Modern Language Association (MLA)
Gao, Jia-Yang…[et al.]. Association between a TCF4 Polymorphism and Susceptibility to Schizophrenia. BioMed Research International No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1131462
American Medical Association (AMA)
Gao, Jia-Yang& Ma, Pan& Li, Ying& Yan, Chunxia& Zhang, Qian& Yang, Xi-Xi…[et al.]. Association between a TCF4 Polymorphism and Susceptibility to Schizophrenia. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1131462
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131462