CXCR7 Inhibits Fibrosis via Wntβ-Catenin Pathways during the Process of Angiogenesis in Human Umbilical Vein Endothelial Cells
Joint Authors
Yuan, Yuan-zhi
Yuan, Fei
Feng, Yi-fan
Shen, MinQian
Wang, Jing
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-05
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Although SDF-1/CXCR7 plays an important role in angiogenesis, the function and the pathway of the SDF-1/CXCR7 axis might depend on the cell type or tissue origin and not fully understood.
In this study, we investigated the effect of CXCR7 in SDF-1-induced proliferation, migration, apoptosis, tube formation, and endothelial-to-mesenchymal transition (EndMT) of human umbilical vein endothelial cells (HUVECs), and the potential pathway of SDF-1/CXCR7.
We confirmed that the silencing of CXCR7 inhibited the proliferation of HUVECs and contributed the apoptosis, while overexpressed CXCR7 increased SDF-1-induced HUVECs migration and tube formation.
However, upregulated CXCR7 inhibited the expression of α-SMA, suggesting that CXCR7 might attenuate EndMT.
In addition, overexpressed CXCR7 activated AKT and ERK signaling pathways but suppressed Wnt/β-catenin pathways in HUVECs.
The inhibition of Wnt/β-catenin pathways decreased the expression of α-SMA.
Altogether, these results suggest that CXCR7 might inhibit fibrosis via Wnt/β-catenin pathways during the process of angiogenesis.
American Psychological Association (APA)
Shen, MinQian& Feng, Yi-fan& Wang, Jing& Yuan, Yuan-zhi& Yuan, Fei. 2020. CXCR7 Inhibits Fibrosis via Wntβ-Catenin Pathways during the Process of Angiogenesis in Human Umbilical Vein Endothelial Cells. BioMed Research International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1131469
Modern Language Association (MLA)
Shen, MinQian…[et al.]. CXCR7 Inhibits Fibrosis via Wntβ-Catenin Pathways during the Process of Angiogenesis in Human Umbilical Vein Endothelial Cells. BioMed Research International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1131469
American Medical Association (AMA)
Shen, MinQian& Feng, Yi-fan& Wang, Jing& Yuan, Yuan-zhi& Yuan, Fei. CXCR7 Inhibits Fibrosis via Wntβ-Catenin Pathways during the Process of Angiogenesis in Human Umbilical Vein Endothelial Cells. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1131469
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131469