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Effect of Saffron Extract and Crocin in Serum Metabolites of Induced Obesity Rats
Joint Authors
Azlan, Azrina
Abas, Faridah
Ramli, Fatin Najwa
Abu Bakar Sajak, Azliana
Mat Daud, Zulfitri Azuan
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-09
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
The effect of saffron extract (Crocus sativus L.) and its primary compound crocin was studied on an induced obesity rat model.
Our study is aimed at investigating and comparing the metabolite changes in obese and obese treated with saffron extract and crocin and at improving the understanding of the therapeutic effect of saffron extract and crocin.
Two different doses of saffron extracts and crocin (40 and 80 mg/kg) were incorporated in a high-fat diet (HFD) and were given for eight weeks to the obese rats.
The changes in metabolite profiles of the serum were determined using proton nuclear magnetic resonance (1H-NMR).
Pattern recognition by multivariate data analysis (MVDA) showed that saffron extract and crocin at 80 mg/kg was the best dosage compared to 40 mg/kg.
It also showed that both treatments work in different pathways, especially concerning glucose, lipid, and creatinine metabolism.
In conclusion, although the pure compound, crocin, is superior to the saffron crude extract, this finding suggested that the saffron extract can be considered as an alternative aside from crocin in treating obesity.
American Psychological Association (APA)
Ramli, Fatin Najwa& Abu Bakar Sajak, Azliana& Abas, Faridah& Mat Daud, Zulfitri Azuan& Azlan, Azrina. 2020. Effect of Saffron Extract and Crocin in Serum Metabolites of Induced Obesity Rats. BioMed Research International،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1131484
Modern Language Association (MLA)
Ramli, Fatin Najwa…[et al.]. Effect of Saffron Extract and Crocin in Serum Metabolites of Induced Obesity Rats. BioMed Research International No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1131484
American Medical Association (AMA)
Ramli, Fatin Najwa& Abu Bakar Sajak, Azliana& Abas, Faridah& Mat Daud, Zulfitri Azuan& Azlan, Azrina. Effect of Saffron Extract and Crocin in Serum Metabolites of Induced Obesity Rats. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1131484
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131484