Roles of Reactive Oxygen Species in Biological Behaviors of Prostate Cancer
Joint Authors
Han, Chenglin
Wang, Zilong
Xu, Yingkun
Chen, Shuxiao
Han, Yuqing
Li, Lin
Wang, Muwen
Jin, Xunbo
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-29
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Prostate cancer (PCa), known as a heterogenous disease, has a high incidence and mortality rate around the world and seriously threatens public health.
As an inevitable by-product of cellular metabolism, reactive oxygen species (ROS) exhibit beneficial effects by regulating signaling cascades and homeostasis.
More and more evidence highlights that PCa is closely associated with age, and high levels of ROS are driven through activation of several signaling pathways with age, which facilitate the initiation, development, and progression of PCa.
Nevertheless, excessive amounts of ROS result in harmful effects, such as genotoxicity and cell death.
On the other hand, PCa cells adaptively upregulate antioxidant genes to detoxify from ROS, suggesting that a subtle balance of intracellular ROS levels is required for cancer cell functions.
The current review discusses the generation and biological roles of ROS in PCa and provides new strategies based on the regulation of ROS for the treatment of PCa.
American Psychological Association (APA)
Han, Chenglin& Wang, Zilong& Xu, Yingkun& Chen, Shuxiao& Han, Yuqing& Li, Lin…[et al.]. 2020. Roles of Reactive Oxygen Species in Biological Behaviors of Prostate Cancer. BioMed Research International،Vol. 2020, no. 2020, pp.1-19.
https://search.emarefa.net/detail/BIM-1131501
Modern Language Association (MLA)
Han, Chenglin…[et al.]. Roles of Reactive Oxygen Species in Biological Behaviors of Prostate Cancer. BioMed Research International No. 2020 (2020), pp.1-19.
https://search.emarefa.net/detail/BIM-1131501
American Medical Association (AMA)
Han, Chenglin& Wang, Zilong& Xu, Yingkun& Chen, Shuxiao& Han, Yuqing& Li, Lin…[et al.]. Roles of Reactive Oxygen Species in Biological Behaviors of Prostate Cancer. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-19.
https://search.emarefa.net/detail/BIM-1131501
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131501