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The Place of PET to Assess New Therapeutic Effectiveness in Neurodegenerative Diseases
Joint Authors
Guilloteau, Denis
Ribeiro, Maria-Joao
Dupont, Anne-Claire
Largeau, Bérenger
Arlicot, Nicolas
Source
Contrast Media & Molecular Imaging
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-17
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
In vivo exploration of neurodegenerative diseases by positron emission tomography (PET) imaging has matured over the last 20 years, using dedicated radiopharmaceuticals targeting cellular metabolism, neurotransmission, neuroinflammation, or abnormal protein aggregates (beta-amyloid and intracellular microtubule inclusions containing hyperphosphorylated tau).
The ability of PET to characterize biological processes at the cellular and molecular levels enables early detection and identification of molecular mechanisms associated with disease progression, by providing accurate, reliable, and longitudinally reproducible quantitative biomarkers.
Thus, PET imaging has become a relevant imaging method for monitoring response to therapy, approved as an outcome measure in bioclinical trials.
The aim of this paper is to review and discuss the current inputs of PET in the assessment of therapeutic effectiveness in neurodegenerative diseases connected by common pathophysiological mechanisms, including Parkinson’s disease, Huntington’s disease, dementia, amyotrophic lateral sclerosis, multiple sclerosis, and also in psychiatric disorders.
We also discuss opportunities for PET imaging to drive more personalized neuroprotective and therapeutic strategies, taking into account individual variability, within the growing framework of precision medicine.
American Psychological Association (APA)
Dupont, Anne-Claire& Largeau, Bérenger& Guilloteau, Denis& Ribeiro, Maria-Joao& Arlicot, Nicolas. 2018. The Place of PET to Assess New Therapeutic Effectiveness in Neurodegenerative Diseases. Contrast Media & Molecular Imaging،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1131520
Modern Language Association (MLA)
Dupont, Anne-Claire…[et al.]. The Place of PET to Assess New Therapeutic Effectiveness in Neurodegenerative Diseases. Contrast Media & Molecular Imaging No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1131520
American Medical Association (AMA)
Dupont, Anne-Claire& Largeau, Bérenger& Guilloteau, Denis& Ribeiro, Maria-Joao& Arlicot, Nicolas. The Place of PET to Assess New Therapeutic Effectiveness in Neurodegenerative Diseases. Contrast Media & Molecular Imaging. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1131520
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131520