LRG1 May Accelerate the Progression of ccRCC via the TGF-β Pathway
Joint Authors
Chen, Xiangmei
Wang, Shuqiang
Hong, Quan
Liu, Shuxin
Cai, Guangyan
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Clear cell renal cell carcinoma (ccRCC) accounts for 60-70% of renal cell carcinoma (RCC) cases.
It is an urgent mission to find more therapeutic targets for advanced ccRCC.
Leucine-rich a-2-glycoprotein 1 (LRG1) is a secreted protein associated with a variety of malignancies.
Our study focused on the expression and mechanism of LRG1 in ccRCC based on data from The Cancer Genome Atlas (TCGA) and provided primary verification including LRG1 expression detection, LRG1 gene methylation detection, and downstream signaling detection.
We found that LRG1 was overexpressed in ccRCC kidney tissue samples, and the methylation level of LRG1 gene was significantly decreased in ccRCC.
Moreover, the expression of LRG1 was negatively related to patient survival.
Based on our previous study and the verification reported in this article, we propose that demethylation-induced overexpression of LRG1 is likely to accelerate ccRCC progression via the TGF-β pathway.
American Psychological Association (APA)
Hong, Quan& Wang, Shuqiang& Liu, Shuxin& Chen, Xiangmei& Cai, Guangyan. 2020. LRG1 May Accelerate the Progression of ccRCC via the TGF-β Pathway. BioMed Research International،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1131534
Modern Language Association (MLA)
Hong, Quan…[et al.]. LRG1 May Accelerate the Progression of ccRCC via the TGF-β Pathway. BioMed Research International No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1131534
American Medical Association (AMA)
Hong, Quan& Wang, Shuqiang& Liu, Shuxin& Chen, Xiangmei& Cai, Guangyan. LRG1 May Accelerate the Progression of ccRCC via the TGF-β Pathway. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1131534
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131534