Dunaliella salina Attenuates Diabetic Neuropathy Induced by STZ in Rats: Involvement of Thioredoxin
Joint Authors
El-Baz, Farouk K.
Salama, Abeer
Salama, Rania A. A.
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-08
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Diabetic neuropathy (DN) is a widespread disabling disorder including peripheral nerves’ damage.
The aim of the current study was to estimate the potential ameliorative effect of Dunaliella salina (D.
salina) on DN and the involvement of the thioredoxin.
Diabetes was induced by streptozotocin (STZ; 50 mg/kg; i.p).
Glimepiride (0.5 mg/kg) or D.
salina powder (100 or 200 mg/kg) were given orally, after 2 days of STZ injection for 4 weeks.
Glucose, total antioxidant capacity (TAC), superoxide dismutase (SOD), and catalase (CAT) serum levels as well as brain contents of thioredoxin (Trx), tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6) were measured with the histopathological study.
STZ-induced DN resulted in a significant (P<0.05) rise in glucose blood level and brain contents of TNF-α and IL-6 and produced a reduction in serum TAC, SOD, CAT, and brain Trx levels with irregular islets of Langerhans cells and loss of brain Purkinje cells.
Treatment with glimepiride or both doses of D.
salina alleviated these biochemical and histological parameters as compared to the STZ group.
D.
salina has a neurotherapeutic effect against DN via its inhibitory effect on inflammatory mediators and oxidative stress molecules with its upregulation of Trx activity.
American Psychological Association (APA)
El-Baz, Farouk K.& Salama, Abeer& Salama, Rania A. A.. 2020. Dunaliella salina Attenuates Diabetic Neuropathy Induced by STZ in Rats: Involvement of Thioredoxin. BioMed Research International،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1131537
Modern Language Association (MLA)
El-Baz, Farouk K.…[et al.]. Dunaliella salina Attenuates Diabetic Neuropathy Induced by STZ in Rats: Involvement of Thioredoxin. BioMed Research International No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1131537
American Medical Association (AMA)
El-Baz, Farouk K.& Salama, Abeer& Salama, Rania A. A.. Dunaliella salina Attenuates Diabetic Neuropathy Induced by STZ in Rats: Involvement of Thioredoxin. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1131537
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131537