![](/images/graphics-bg.png)
Comparative Transcriptome Analysis Reveals the Potential Cardiovascular Protective Targets of the Thyroid Hormone Metabolite 3-Iodothyronamine (3-T1AM)
Joint Authors
Haiyan, Zhou
Bailong, Hu
Bei, Zhang
Yiming, Wang
Xingde, Liu
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
The thyroid hormone metabolite 3-iodothyronamine (3-T1AM) is rapidly emerging as a promising compound in decreasing the heart rate and lowering the cardiac output.
The aim of our study was to fully understand the molecular mechanism of 3-T1AM on cardiomyocytes and its potential targets in cardiovascular diseases.
Materials and Methods.
In our study, we utilized RNA-Seq to characterize the gene expression in H9C2 cells after 3-T1AM treatment.
Comparative transcriptome analysis, including gene ontology, signaling pathways, disease connectivity analysis, and protein-protein interaction networks (PPI), was presented to find the critical gene function, hub genes, and related pathways.
Results.
A total of 1494 differently expressed genes (DEGs) were identified (192 upregulated and 1302 downregulated genes) in H9C2 cells for 3-T1AM treatment.
Of these, 90 genes were associated with cardiovascular diseases.
The PPI analysis indicated that 5 hub genes might be the targets of 3-T1AM.
Subsequently, eight DEGs characterized using RNA-Seq were confirmed by RT-qPCR assays.
Conclusions.
Our study provides a comprehensive analysis of 3-T1AM on H9C2 cells and delineates a new insight into the therapeutic intervention of 3-T1AM for the cardiovascular diseases.
American Psychological Association (APA)
Haiyan, Zhou& Bailong, Hu& Bei, Zhang& Yiming, Wang& Xingde, Liu. 2020. Comparative Transcriptome Analysis Reveals the Potential Cardiovascular Protective Targets of the Thyroid Hormone Metabolite 3-Iodothyronamine (3-T1AM). BioMed Research International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1131544
Modern Language Association (MLA)
Haiyan, Zhou…[et al.]. Comparative Transcriptome Analysis Reveals the Potential Cardiovascular Protective Targets of the Thyroid Hormone Metabolite 3-Iodothyronamine (3-T1AM). BioMed Research International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1131544
American Medical Association (AMA)
Haiyan, Zhou& Bailong, Hu& Bei, Zhang& Yiming, Wang& Xingde, Liu. Comparative Transcriptome Analysis Reveals the Potential Cardiovascular Protective Targets of the Thyroid Hormone Metabolite 3-Iodothyronamine (3-T1AM). BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1131544
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131544