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Functionalization of Gadolinium Chelates Silica Nanoparticle through Silane Chemistry for Simultaneous MRI64Cu PET Imaging
Joint Authors
Tillement, Olivier
Lux, François
Tran, Vu-Long
Thakare, Vivek
Natuzzi, Marco
Moreau, Mathieu
Oudot, Alexandra
Vrigneaud, Jean-Marc
Courteau, Alan
Louis, Cédric
Roux, Stéphane
Boschetti, Frédéric
Denat, Franck
Source
Contrast Media & Molecular Imaging
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-01
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Multimodal nanoprobes are highly demanded for biomedical imaging applications to enhance the reliability of the diagnostic results.
Among different types of nano-objects, ultrasmall silica gadolinium nanoparticle (SiGdNP) appears as a safe, effective, and versatile platform for this purpose.
In this study, a new method to functionalize SiGdNP based on silane chemistry has been reported.
Two types of chelating silanes (APTES-DOTAGA and APTES-NODAGA) have been synthesized and grafted on SiGdNP by a simple one-step protocol.
This functionalization strategy requires no other reactants or catalyzers and does not compromise the ultrasmall size of the particles.
NODAGA-functionalized particle has been labeled with 64Cu isotope and injected intravenously to mice bearing TS/A carcinoma tumor for biodistribution study to demonstrate its potential as a bimodal MRI/PET imaging agent.
A fully integrated MRI/PET system was used to simultaneously monitor the distribution of the particle.
The results showed that the functionalized particle maintained properties of a renal clearable NP which could rapidly escape through kidneys and had low retention in other organs, especially liver, even though its accumulation in the tumor was modest.
American Psychological Association (APA)
Tran, Vu-Long& Thakare, Vivek& Natuzzi, Marco& Moreau, Mathieu& Oudot, Alexandra& Vrigneaud, Jean-Marc…[et al.]. 2018. Functionalization of Gadolinium Chelates Silica Nanoparticle through Silane Chemistry for Simultaneous MRI64Cu PET Imaging. Contrast Media & Molecular Imaging،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1131552
Modern Language Association (MLA)
Tran, Vu-Long…[et al.]. Functionalization of Gadolinium Chelates Silica Nanoparticle through Silane Chemistry for Simultaneous MRI64Cu PET Imaging. Contrast Media & Molecular Imaging No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1131552
American Medical Association (AMA)
Tran, Vu-Long& Thakare, Vivek& Natuzzi, Marco& Moreau, Mathieu& Oudot, Alexandra& Vrigneaud, Jean-Marc…[et al.]. Functionalization of Gadolinium Chelates Silica Nanoparticle through Silane Chemistry for Simultaneous MRI64Cu PET Imaging. Contrast Media & Molecular Imaging. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1131552
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131552